交变磁场对神经内分泌活动的影响与止痛效应

目的探讨旋转的恒定磁场对神经内分泌活动的影响及与止痛的关系,从而探索磁场止痛的机制.方法用WD-6000多功能治疗仪(恒定磁场强度为0.6T,转速为240 r/min)对10只新西兰兔和30例运动系统疾病或癌症疼痛患者进行磁场处理,9例患者(对照组)接受假磁场处理.分别在处理前后抽取血样,用放射免疫方法测定其血浆中β-内啡肽含量.结果磁场处理后新西兰兔血浆β-内啡肽浓度为(83.7±9.8)pmol/L,显著高于处理前[(38.3±15.2)pmol/L](t=8.69,P＜0.01);实验组分别为(8.7±3.0),(58.2±21.6)pmol/L(t=12.48,P＜0.01).对照组的血浆β-内啡肽浓度在处理前后差异无显著性意义[(8.7±0.5),(9.4±0.7)pmol/L](t=1.00,P＞0.05).结论磁场能促使机体血浆β-内啡肽显著升高.此种变化是构成磁场止痛的内在基础之一.

Influence of alternating magnetic field on neuroendocrine and its analgesic effect

AIM: To investigate the relationship between the influence of rotating and stationary magnetic field on neuroendocrine and its analgesic effect so as to explore the analgesic mechanism of magnetic field. METHODS: New Zealand rabbits and voluntary patients with pain were treated with magnetic field, using the HMF-6 000 multifunctional therapeutic equipment(magnetic field intensity of 0. 6 T and rotational speed of 240 r/ min). Blood samples were collected before and after the treatment to measure the contents of plasma β-endorphin with radioimmunoassy. RESULTS:The mean plasma β-endorphin concentration of rabbits after the magnetic field treatment was (83.7 ± 9.8) pmol/L, significantly higher than that before the magnetic field treatment[ (38.3± 15.2)pmol/L] (t = 8.69, P ＜ 0.01 ). The mean plasma β-endorphin concentration of the patients with pain after the magnetic field treatment was (58.2 ± 21.6) pmol/L, significantly higher than that before the magnetic field management[ (8.7 ± 3.0) pmo/L] ( t = 12.48, P ＜ 0.01 ). However, the concentration of plas- ma β-endorphin patients in the control group was not significantly different after fake magnetic field management [ (8.7 ± 0.5 ) pmol/L vs (9.4 ± 0.7) pmo/L](t= 1.00, P ＞ 0.05). CONCLUSION: Magnetic field management increases the blood concentration of plasma β-endorphin, which may be the internal basis of analgesic effect of magnetic field management.