绝经前女性风湿病患者骨密度变化影响因素分析

目的:对绝经前女性系统性红斑狼疮(SLE)与类风湿关节炎(RA)患者进行骨密度(BMD)的监测,评估发生骨量丢失的原因。方法:采用超声骨密度仪测量89例绝经前女性患者(SLE49例,RA40例)及68例健康志愿者(对照组)右跟骨部位的BMD,同时对患者诸多影响BMD的因素(年龄、病程、疾病活动度、激素使用时间、激素累积剂量及激素日剂量)与BMD进行相关分析及多元回归分析。结果:患者右跟骨部位的BMD(SLE为-1.42±0.56,RA为-1.36±0.63)明显低于对照组(-0.58±0.52,P<0.01),骨质疏松的发生率(SLE为17.1%,RA为13.3%)明显高于对照组(P<0.01)。线性相关分析结果显示SLE患者的BMD与C3呈正相关(r=0.521,P<0.01),与激素累积剂量呈负相关(r=-0.398,P<0.05);BMD与RA患者的CRP呈负相关(r=-0.431,P<0.05)。多元回归分析提示C3下降与激素累积剂量增高为SLE患者BMD下降的独立危险因素,CRP升高为RA患者BMD下降的独立危险因素。结论:绝经前女性SLE与RA患者骨质疏松的发生率较正常人群明显增高。SLE与RA患...

Factors associated with Bone mineral density in premenopausal women with rheumatic disorders

0bjective　To evaluate the relationship between disease-related variables and bone mineral density (BMD) in premenopausal women with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Methods 89 patients (SLE=49,RA =40) and 40 healthy controls (matched for age) were enrolled in a cross-sectional study between 2007 and 2008. BMD of the calcaneus were measured by Osteospace ultrasonic bone density apparatus . The correlation between BMD and cumulative dose of steroids, daily dose of steroid, disease duration, disease activity, and age was investigated. Results: BMD in the patients ((TSLE=－1.42±0.56，TRA＝－1.36±0.63)) was significantly lower than controls (Tctrl=－0.58±0.52, P=<0.001). The percentage of osteoporosis in patients was 17.1％ in SLE and 13.3% in RA ,which was significantly higher than that of healthy controls(2.2％，P