RNA tumor virus phosphoproteins: subvirion location of the multiple phosphorylated species. |
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Authors: | B K Pal P Roy-Burman |
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Affiliation: | Departments of Pathology and Biochemistry, University of Southern California School of Medicine, Los Angeles, California 90033, USA |
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Abstract: | An analysis of core particles of 1.23 g/cm3 density of the endogenous feline type C virus (RD-114) showed the presence of all of the major low molecular weight structural proteins, namely p30, p12, p10, and the phosphoprotein pp15, in relative proportions similar to those detected in intact RD-114 virions. The protein kinase activity of the virus was also found to be associated with the core. A comparison of the content of multiple phosphorylated species of the pp15 derived from the core with that isolated from the whole virion demonstrated that all major phosphorylated species of RD-114 pp15 were located in the core structure. |
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Keywords: | Author to whom reprint requests should be addressed. |
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