注射用两性霉素B脂质体致呼吸困难 |
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引用本文: | 李悦,贾博军,温静.注射用两性霉素B脂质体致呼吸困难[J].中国药物应用与监测,2012,0(6):370-371. |
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作者姓名: | 李悦 贾博军 温静 |
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作者单位: | 解放军总医院血液科 |
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摘 要: | 1例7岁女性儿童,确诊急性淋巴细胞白血病3年,既往无药物和食物过敏史。治疗期间在第一次使用注射用两性霉索B脂质体30min,出现呼吸困难、寒战、体温39℃,无头痛、低血压。立即停止输注注射用两性霉素B脂质体,给予盐酸异丙嗪注射液10mg肌肉注射、注射用赖氨匹林0.45g入莫菲氏管,30min后症状缓解,4h后体温降至正常,5h后继续使用该药物,未再发生类似反应。
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关 键 词: | 呼吸困难 注射用两性霉素B脂质体 药品不良反应 |
One case of decompensation caused by amphotericin B liposome for injection |
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Authors: | LI Yue JIA Bo-jun WEN Jing |
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Institution: | (Department of Hematology,PLA General Hospital,Beijing 100853,China) |
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Abstract: | One 7-year-old female patient without drug and food allergy history was diagnosed with acute lymphoblastic leukemia three years ago. Thirty minutes after the first use of amphotericin B liposome for injection, she developed dyspnea, shivering and hyperpyrexia (with the temperature of 39 ~2), while no headache and low blood pressure were found. Amphotericin B liposome for injection was withdrawn immediately. She received the intramuscular injection of promethazine hydrochloride injection 10 mg and intravenous injection of lysine-aspirin 0.45 g. After 30 minutes, her symptoms had relief, 4 hours later, the temperature dropped to normal. While this drug was used again after 5 hours, no similar reaction happened. |
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Keywords: | Decompensation Amphotericin B liposome for injection Adverse drug reaction |
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