| 冠心病患者血浆内皮素水平与心脏收缩功能的研究 |
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| 引用本文： | 肖继明,徐军,陈锐华.冠心病患者血浆内皮素水平与心脏收缩功能的研究[J].医学研究生学报,2008,21(11). |
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| 作者姓名： | 肖继明 徐军 陈锐华 |
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| 作者单位： | 南京军区南京总医院心脏内科,江苏南京,210002 |
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| 基金项目： | 江苏省六大人才高峰重点课题基金资助项目 |
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| 摘 要： | 目的:观察冠心病(CHD)患者血浆内皮素(ET)水平的动态变化,并探讨其与心脏收缩功能的关系. 方法:对62例CHD患者应用免疫放射分析方法(IRMA)测定发病后12、24、48、96 h和7 d的血浆ET水平.应用心脏超声测定其左心室射血分数(LVEF);并按纽约心脏协会(NYHA)分级标准进行临床心功能评定. 结果:CHD患者血浆ET水平显著高于正常对照组(P<0.05),发病12 h即达到峰值,急性心肌梗死(AMI)组和心绞痛(AP)组分别为(127.9±24.1)和(84.1±20.3)ng/L.心功能不全患者ET水平高于心功能正常者,心功能Ⅰ,Ⅱ,Ⅲ,Ⅳ级患者的ET分别为(79.8±16.3)、(86.9±18.2)、(121.2±24.6)和(192.1±22.2)ng/L.进一步相关分析显示,血浆ET水平与LVEF值呈显著负相关(r=-0.26,P<0.05). 结论:CHD患者血浆ET水平在发病后12 h达到峰值,其升高程度不仅与心功能分级有相关性,而且可反映心脏收缩功能的受损程度.
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| 关 键 词： | 冠心病 内皮素 心功能 |
Correlation between myocardial function and plasma endothelin in patients with coronary heart disease |
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| XIAO Ji-ming,XU Jun,CHEN Rui-hua.Correlation between myocardial function and plasma endothelin in patients with coronary heart disease[J].Bulletin of Medical Postgraduate,2008,21(11). |
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| Authors: | XIAO Ji-ming XU Jun CHEN Rui-hua |
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| Institution: | XIAO Ji-ming,XU Jun,CHEN Rui-hua(Department of Cardiology,Nanjing General Hospital of Nanjing Military Comm,,PLA,Nanjing 210002,Jiangsu,China) |
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| Abstract: | Objective: To investigate the dynamic changes in the content of endothelin(ET) in the plasma of coronary heart disease(CHD) patients and the relationship between myocardial function and ET.Methods: The plasma ET levels of 62 CHD patients were measured by immunoradiometric assay(IRMA) at 12 h,24 h,48 h,96 h and 7 d after the attack of CHD.The left ventricular ejection fraction(LVEF) was detected by echocardiography and the cardiac function was assessed according to the NYHA classification criteria.Results: T... |
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| Keywords: | Coronary heart disease Endothelin Heart function |
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