| HPLC法测定洛索洛芬钠渗透泵型控释片的含量 |
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| 引用本文： | 杨甜,王成永.HPLC法测定洛索洛芬钠渗透泵型控释片的含量[J].安徽医药,2010,14(3):293-294. |
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| 作者姓名： | 杨甜 王成永 |
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| 作者单位： | 安徽中医学院药学院,安徽,合肥,230038;安徽中医学院药学院,安徽,合肥,230038 |
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| 摘 要： | 目的建立洛索洛芬钠渗透泵型控释片中洛索洛芬钠的含量测定方法。方法采用HPLC法，色谱柱：日本岛津VP—DOS柱（150mm×4．6mm，5μm）；流动相：甲醇-水-冰醋酸-三乙胺（600：400：1：1）；检测波长：222nm；流速：1．00ml·min^-1；柱温：25℃。结果洛索洛芬钠在30．18～110．66mg·L^-1范围内呈良好的线性关系（r=0．9998），平均回收率为99．83％，RSD=0．48％（n=9）。结论该方法简便、准确、重现性好。适用于洛索洛芬钠渗透泵型控释片中主药的含量测定。
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| 关 键 词： | 高效液相色谱法 洛索洛芬钠 含量测定 |
Determination of loxoprofen sodium osmotic pump controlled release tablets by HPLC |
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| YANG Tian,WANG Cheng-yong.Determination of loxoprofen sodium osmotic pump controlled release tablets by HPLC[J].Anhui Medical and Pharmaceutical Journal,2010,14(3):293-294. |
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| Authors: | YANG Tian WANG Cheng-yong |
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| Institution: | Department of Pharmacy;Anhui University of Traditional Chinese Medicine;Hefei;Anhui 230038;China |
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| Abstract: | Aim To establish a method for the determination of loxoprofen sodium in loxoprofen sodium osmotic pump controlled release tablets.Method HPLC was performed on a Shim-pack VP-DOS column.The mobile phase was methanol-water-acetic acid-triethylamine(600∶400∶1∶1).The detection wavelength was set at 222 nm.The flow rate was 1.00 ml·min-1.The column temperature was 25℃.Results The linear range of loxoprofen sodium was from 30.18 to 110.66 mg·L-1(r=0.9998).The average recovery rate was 99.83% with an RSD of 0.48%(n=9).Conclusion The method is simple,accurate and repeatable which can be used for the determination of loxoprofen sodium in loxoprofen sodium osmotic pump controlled release tablets. |
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| Keywords: | HPLC loxoprofen sodium determination |
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