溴化异丙托品对稳定期COPD患者肺功能及运动耐受性的影响

目的 观察不同剂量的溴化异丙托品（ＩＰＢ）短时及长期应用，对稳定期慢性阻塞性肺疾病（ＣＯＰＤ）患者的肺功能及运动耐受性的影响。方法 ３７例稳定期ＣＯＰＤ患者，随机分３组，分别吸人ＩＰＢ１６０μｇ／次、８０μｇ／次、４０μｇ／次。用药前后行肺功能及自行车功量仪极量运动负荷法运动试验测验。结果 吸入ＩＰＢ１６０μｇ／次、８０μｇ／次组与安慰剂对照组相比，通气及运动指标均明显改善（Ｐ〈０．０１、Ｐ〈０．

The impact of ipratropium bromide on lung function and exercise tolerance in patients with stable chronic obstructivepulmonary disease

Objective To compare the effects of varying doses of inhaled ipratropium bromide (TPB) and theimpact on lung function and exercise tolerance using progressive cycle ergometry in-patients with stable COPD. Methods Thirty seven patients with stable COPD of mean age 57. 4 years and forced expiratory volume in one second(FEV1.0) of 1.66 (0.50) L, were studied by progressive exercise tests on a cycle ergometry in a randomized double-blind manner, these and placebo were administered with metered-dose inhalers. Each of the three different dosagegroups received ipratropium bromide at 160 μg,80 μg and 40 μg. The effects on the maximal ventilation (VEmax),heart rate, SaO2, maximal work rate (Wmax), oxygen uptake (VO2max) were determined at rest and at maximalworkloads among the three different dosages groups. Results Ipratropium bromide at the dosages of 160 μg, 80 μgproduced a greater increase in FEV1 VO2max, Wmax, VEmax than 40 μg or placebo. (P＜0.01 ,P＜0.05) 40 μg rid fortwo weeks didn't produce greater improvement except in FEV1 and VEmax. No changes were found in heart rate,blood pressure and SaO2. No side effects were noted. Conclusion Ipratropium bromide can improve the ventilation,dyspnoea and exercise tolerance in patients with stable COPD, but has no significant effects on the cardiovascular sys-tem. (Shanghai Med J, 2000,23: 606-609)