银川吴忠两市儿童青少年维生素D营养状况

了解宁夏银川、吴忠两市儿童青少年维生素D营养状况,为预防儿童青少年维生素D不足与缺乏提供合理依据.方法 在银川市2区和吴忠市随机抽取小学、初中和高中,采用分层整群抽样的方法抽取班级.排除佝偻病、克罗恩病、心血管疾病及肝肾疾病患者,以及近3月内服用过维生素D补充剂的儿童青少年,共选取7~18岁对象2 167名.采集研究对象空腹静脉血,采用酶联免疫吸附法(ELISA法)测定其血清25(OH)D的浓度.结果 银川、吴忠两市儿童青少年血清25(OH)D浓度中位数为51.46 nmol/L,四分位数间距为61.46 nmol/L,维生素D充足、不足、缺乏检出率分别为51.9%,14.1%,34.0%.不足检出率以7岁最高,8~13岁随着年龄的增长呈升高趋势,至14岁开始逐渐降低.7~18岁各年龄组儿童青少年缺乏检出率依次为31.9%,27.9%,20.8%,30.1%,36.7%,2.4%,29.8%,32.3%,35.3%,47.5%,37.3%,32.8%,各年龄组均较高.不同年龄组间维生素D水平及缺乏检出率比较,差异均有统计学意义(H=43.086,P<0.01;x2=11.156,P=0.001).回、汉族儿童青少年维生素D水平、不足与缺乏检出率比较,差异均无统计学意义(P值均>0.05).结论 银川、吴忠两市7~18岁儿童青少年维生素D水平较低,维生素D缺乏检出率较高;随年龄增长,儿童青少年血清维生素D水平逐渐降低,不足、缺乏检出率升高.

Nutritional status of vitamin D among children and adolescents in Yinchuan and Wuzhong

Objective To investigate the nutritional status of vitamin D among children and adolescents in Yinchuan and Wuzhong city of Ningxia,and to provide a scientific reference for the prevention of Vitamin D insufficiency and deficiency among children and adolescents.Methods Stratified cluster samphng method was used to extract classes from the randomly-selected primary,middle and high schools of Yinchuan and Wuzhong city.The patients of rickets,Crohn's disease,cardiovascular disease,liver and kidney disease,and the children and adolescents with Vitamin D supplements history in the last 3 months were excluded.2 167 children and adolescents aged from 7 to 18 were selected as subjects.The fasting venous blood was collected and the concentration of serum 25(OH) D was determined by enzyme-linked immunosorbent assay(ELISA).Results The serum 25 (OH) D concentration among 2 167 children and adolescents was 51.46nmol/L,the interquartile distance was 61.46 nmol/L,the sufficient,insufficient and deficient detection rates of vitamin D were 51.9%,14.1% and 34.0%,respectively.The detection rate of insufficiency was at the highest at 7 years old,and then showed an upward tendecny during 8-13 years old with increasing of age,while started to decrease gradually at the age of 14.The deficiency detection rates of children aged 7-18 years were 31.9%,27.9%,20.8%,30.1%,36.7%,42.4%,29.8%,32.3%,35.3%,47.5%,37.3% and 32.8%,respectively.The differences of Vitamin D levels and deficiency detection rates among different age groups were of statistical significance (H =43.086,P< 0.01,x2 =11.156,P =0.001).The differences between Hui and Han children were of no statistical significance for the level of Vitamin D and insufficient and deficiency detection rates.Conclusion The children and adolescents aged 7-18 years in Yinchuan and Wuzhong are found of high detection rate of vitamin D deficiency.With the increase of age,the levels of Vitamin D among children and adolescents decreased,the deficiency detection rate increased significantly.