石家庄某高校学生结核病发病情况及随访观察

了解大学生的结核病发病情况及相关因素,为制定学校结核病防控措施提供依据.方法 选取河北经济管理学院2006级至2009级4届新生,按入学时的TB-PPD试验结果分为阴性组、一般阳性组和强阳性组,每届学生均观察3年,采用回顾性队列研究的方法对在校期间的结核病发病情况进行分析.结果 2006级至2009级共8 414人,有PPD结果8 394人,阳性率、强阳性率分别为2006级39.0%,12.1%;2007级33.6%,7.6%;2008级46.4%,11.2%;2009级50.4%,13.0%,各年级之间差异均有统计学意义(P值均<0.05).阳性率、强阳性率女生均高于男生,差异均有统计学意义(x2值分别为6.003,39.938,P值均<0.05).城市学生的阳性率(47.2%)高于农村学生(39.6%),强阳性率均为10.9%.累计观察25 242人年,共发现结核病人37例,年发病率为146.6/10万.PPD结果阴性组、一般阳性组、强阳性组的发病率差异有统计学意义(x2=132.720,P<0.01),发病率与强阳性率呈正相关(r=1.00,P<0.01).强阳性组中农村学生发病率高于城市(x2 =5.319,P=0.021).结论 青年学生是结核病的高危人群.应做为重点关注对象,给予适当的干预措施.

Follow-up study on the incidence of tuberculosis among students in a college of Shijiazhuang

Objective The incidence of tuberculosis and related factors were studied to provide the guidelines for TB prevention and control in school.Methods 2006-2009 four-year freshman of Hebei Economy Management School were divided into negative group,positive group and strong positive group,according to the PPD test results.All the students were observed for 3 years,and the incidence of tuberculosis was analyzed during the period.Results There were a total of 8 414 students,the positive rate and strong positive rate were significant differences between 4 grades,as following:2006 session 39.0%,12.1%;2007 session 33.6%,7.6%;2008 session 46.4%,11.2%;2009 session 50.4%,13.0%.Positive rate and strong positive rate were different in different gender,and the positive rate of female was higher than that of male.The positive rate of urban origin students was 47.2% higher than that of rural,and the strong positive rate of them both were 10.9%.The accumulation of 25 242 person years was observed in this subject.A total of 37 TB patients were found,and the incidence rate was 146.6/105.The incidence of negative group,positive group and strong positive group were significantly different,and the incidence rate was positively correlated with the strong positive rate (r=1,P<0.01).In addition,the study also found that the source of strong positive group in rural incidence rate was far higher than that in city (x2 =5.319,P=0.021).Conclusion Young students with high risk of tuberculosis infection,especially students with strong positive PPD test,should be as the focus of concern,given appropriate interventions to reduce the incidence of tuberculosis.