岩藻糖转移酶9在乳腺癌中的表达及其临床意义

目的 本研究探讨岩藻糖转移酶9（fucosyltransferase9,FUT9）在乳腺癌组织中的表达及其与乳腺癌临床病理因素的关系。方法 采用免疫组织化学SP法检测11例良性乳腺增生组织和114例乳腺癌组织（其中47例合并转移淋巴结，67例无转移淋巴结）中FUT9的表达。结果 FUT9在良性乳腺增生组织中的阳性表达率为9.1%（1/11），而在乳腺癌组织中的阳性表达率为71.9%(82/114),在转移的淋巴灶中阳性表达率为100%（47/47）。乳腺癌组织中的阳性表达率明显高于良性乳腺增生组织的阳性表达率，两组比较差异有统计学意义（P<0.01）。乳腺癌组织中有淋巴结转移组的阳性表达率为80.9%（38/47），明显高于无淋巴结转移组的阳性表达率65.7%（44/67），两组比较差异有统计学意义（P<0.05）。在有淋巴结转移组FUT9的表达与TNM分期以及转移的淋巴结个数相关（P<0.05）。FUT9的表达与ER、PR、HER2的表达无相关性（P>0.05）。结论 FUT9在乳腺癌组织中的表达明显增高；FUT9的表达与淋巴结转移、转移的淋巴结个数以及TNM分期有关；FUT9可能与乳腺癌淋巴道转移有关。

Expression of Fucosyltransferase 9 and Its Clinical Significance in Human Breast Carcinoma

Objective This study was to investigate the expression of the fucosyltransferase9 and its clinical significance in human breast carcinoma.Methods FUT9 expression was detected using immunohistochemistry SP method in 11 breast hyperplasia specimens and 114 breast cancer specimens (47 with lymphatic metastasis and 67 without metastasis).Results The positive rate of FUT9 in breast hyperplasia, breast cancer and metastatic lymph node were 9.1%（1/11）,71.9%( 82/114) and 100%（47/47）,respectively. The expression of FUT9 in breast cancer specimens was significantly higher than breast hyperplasia tissues (P<0.01). Breast cancer patients with lymphatic metastasis had higher FUT9 expression rate of 80.9%（38/47）than patients without none lymphatic metastasis 65.7%(44/67). The differences between two groups have statistical significance (P<0.05). We also have found that the expression of FUT9 was positively correlated with TNM staging and the numbers of metastatic lymph nodes in patients (P<0.05）,however the ER status, the PR status and the HER2 status were not associated with FUT9 expression (P>0.05）. Conclusion Expression of FUT9 in breast cancer was positively correlated with malignant progression of disease. Our results strongly suggested that FUT9 may be involved in the process of breast’s lymphatic metastasis.