| 包头地区PPAR-γ2基因多态性与2型糖尿病合并冠心病的相关性研究 |
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| 引用本文： | 王津京,魏枫,高丽君,苏日娜,王云枝,郑玉云,魏建华.包头地区PPAR-γ2基因多态性与2型糖尿病合并冠心病的相关性研究[J].中华糖尿病杂志,2008,16(9):566-567. |
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| 作者姓名： | 王津京 魏枫 高丽君 苏日娜 王云枝 郑玉云 魏建华 |
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| 作者单位： | 包头医学院第一附属医院内分泌科,内蒙古014010 |
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| 基金项目： | 内蒙古包头市医药卫生科技发展基金 |
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| 摘 要： | 选取受试者366例，用PCR-RFLP法测定基因型（包括PP、PA、AA三种基因型，由于AA突变率很低，用X/A作为PA、AA共同代称）。发现单纯T2DM组X/A基因型频率明显低于正常对照组（0.1vs0.28；P〈0.05）；T2DM合并CHD组X/A基因型频率明显高于T2DM组（0.21vs0.1；P〈0.05）。表明在已经发生了T2DM的患者中X/A基因型是T2DM合并CHD发病的一个独立危险因素。
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| 关 键 词： | 多态性 过氧化物酶体增殖物激活受体 糖尿病 2型 冠心病 |
The relationship between polymorphism in PPAR-γ2 gene and coronary heart disease in type 2 diabetes mellitns in baotou, China |
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| Institution: | WANG Jin-jing, WEI Feng, GAO Li-jun, et al(Department of Endocrinology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University Science ＆ Technology ,Baotou 014010 ,China) |
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| Abstract: | The Prol2Ala polymorphism was screened by means of polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） in 366 patients with coronary heart disease （CHD） plus T2DM in Baotou. The frequency of X/A genotype was significantly lower in T2DM than in control（0. 1 vs 0. 28;X^2 = 11.23, P〈0. 05）. The frequency of the X/A genotype was significantly higher in the group of the T2DM plus CHD than in T2DM （0. 21 vs 0. 1;X^2 =4. 06,P〈0. 05）. The genotype of X/A is associated with a increased risk for development of CHD in T2DM in Baotou area. |
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| Keywords: | Polymorphism Peroxisome proliferator-activated receptor Diabetes mellitus type 2 Coronary heart disease |
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