双相障碍不同亚型伴与不伴焦虑障碍的神经心理功能损害的研究

目的：研究双相障碍不同亚型伴有焦虑障碍与不伴焦虑障碍患者临床表现、心理社会功能损害及治疗效果的差异。方法本研究将95例双相障碍患者根据其自身发病特点分成双相I型不伴有焦虑障碍组（28例），双相I型伴有焦虑障碍组（26例），双相Ⅱ型不伴有焦虑障碍组（20例），双相Ⅱ型伴有焦虑障碍组（21例）。同时将健康体检者作为对照组（30例），各组均实施韦氏记忆测验、注意测验及执行功能等神经心理学测验。结果双相I型伴有焦虑障碍组仅在工作记忆方面较不伴焦虑障碍组差，两组在注意及执行功能方面均低于对照组，但两者间的差异无统计学意义；双相Ⅱ型伴有焦虑障碍组在视觉即刻记忆、视觉延迟回忆、工作记忆和精神运动速度方面较不伴焦虑障碍组差。结论双相Ⅱ型伴焦虑障碍的患者在神经心理功能损害方面较双相I型伴有焦虑障碍患者更加严重。

Differences in neuropsychological functions impairment between subtypes of bipolar disorder with or without co-morbid anxiety disorders

Objective To investigate the differences of clinical features between subtypes of bipolar disorder （BP） with or without co- morbid anxiety disorders （ADs）. Methods Ninety- five BP patients were classified into 4 groups： BP- I without AD （n=28）, BP- I with AD（n=26）, BP- II without AD（n=20） and BP- II with AD（n=21）;and 30 healthy subjects（HC） served as controls. Neuropsychological tests were performed in al patients and controls. Results The neuropsychological score of BP- I with AD patients was lower than that of BP- I without patients only in working memory. The neuropsychological scores in visual immediate memory, visual delayed memory, working memory, and psychomotor speed of BP- II with AD patients were significantly lower than those of BP- II without AD patients. Conclusion Our investigation indicates that co- morbid AD would damage the neu-ropsychological performance in BP- II patients more severely than those in BP- I patients.