盐酸多奈哌齐和复方海蛇胶囊联合治疗阿尔茨海默病的研究

目的探讨联合应用盐酸多奈哌齐和复方海蛇胶囊对阿尔茨海默病（AD）患者认知功能和行为能力的改善作用。方法收集AD患者90例，依就诊顺序分为3组，盐酸多奈哌齐和复方海蛇胶囊联合治疗组30例，盐酸多奈哌齐治疗组30例，正常对照组30例。3组患者分别在治疗前和治疗3个月后进行简易精神状态检查表（MMSE）、日常生活活动能力（ADL）量表的测评。结果盐酸多奈哌齐和复方海蛇胶囊联合治疗组患者治疗后认知功能、行为能力较盐酸多奈哌齐治疗组改善明显（P〈0．01）。盐酸多奈哌齐和复方海蛇胶囊联合治疗组治疗后认知功能、行为能力较治疗前改善明显（P〈001）。结论盐酸多奈哌齐和复方海蛇胶囊联合治疗对AD患者认知功能、行为能力有显著改善作用。

Study of the combination of donepezil and compound haishe capsule in therapy of Alzheimer＇s disease

Objective To investigate the improvement of cognitive function and behavioral abilities in Alzheimer＇s disease after treatment with donepezil and compound haishe capsule. Methods 90 patients with Alzheimer＇s disease were randomized into 3 groups： patients in combined group （30 cases） were treated with the combination of donepezil and compound haishe Capsule, patients in donepezil group（30 cases） were treated with donepezil, and patients in control group（30 cases） without any medicine. MMSE and ADL scale were assessed in patients before treatment and 3 months after. Results The cognitive function and behavioral abilities improved significantly in the donepezil group and combined group compared with control group（P〈0.01）, and the improvement of cognitive function was even more in the combined group than donepezil group （P〈0.01）. The behavioral abilities were improved markedly in the donepezil group and combined group （P〈0.01）. Conclusion Congnitive function and behavioral abilities in patients with Alzheimers＇s disease improved markedly after treatment with the combination of donepezil and compound Haishe Capsule.