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头颈部肿瘤螺旋断层放疗中的CTV-PTV边界大小分析
引用本文:胡永,曾昭冲,张建英,张振宇,谈章程.头颈部肿瘤螺旋断层放疗中的CTV-PTV边界大小分析[J].实用肿瘤杂志,2012,27(4):411-414.
作者姓名:胡永  曾昭冲  张建英  张振宇  谈章程
作者单位:复旦大学附属中山医院放疗科,上海,200032
摘    要:目的 探讨螺旋断层放射治疗头颈部肿瘤在六维方向上的摆位误差,并以此误差分析计划靶区(planning target volume,PTV)到临床靶区(clinical target volume,CTV)的预留边界大小.方法 应用兆伏(MV) CT于放疗实施前对24例头颈部肿瘤患者进行扫描,通过自适应软件对重建的容积图像与计划CT扫描图像进行自动匹配和手动调节,记录六维方向上的摆位误差值并调整床位后给予放疗.对记录数据进行统计学分析,计算临床靶体积到计划靶体积的外放边界.结果 24例患者共行327次MVCT扫描,其中摆位偏差在左右、头足和前后方向上的平均平移误差分别是(-0.88 ±2.37)mm、(-1.18±2.82)mm和(1.41±1.82) mm;在倾斜、旋转和偏离三个旋转方向上平均误差分别是(0.15±0.54)°、(0.27±0.96)°和(0.01 ±0.52)°.PTV-CTV外扩边界分别是X轴方向为3.42 mm、Y轴方向为4.33 mm、Z轴方向为4.09 mm.结论 MVCT图像引导下自适应功能在头颈部肿瘤放射治疗中可以有效修正患者的摆位误差,在保证CTV-PTV边界3~5 mm绝对安全的前提下,也保证了单次大剂量放疗肿瘤区域的剂量准确性和对正常组织的充分保护.

关 键 词:头颈部肿瘤/放射疗法  体层摄影术  螺旋计算机  图像处理  计算机辅助  体位  放射疗法/方法

Margin between clinical target volume and planning target volume in helical tomotherapy for head and neck cancer
Institution:HU Yong, ZENG Zhao-chong, ZHANG Jian-ying, et al ( Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China)
Abstract:Objective To evaluate the margin between clinical target volume and planning target volume (CTV-FFV) in helical tomotherapy for patients with head and neck caneer. Methods A total of 327 sets of megavoltage computed tomography (MVCT) images were obtained from 24 head and neck cancer patients treated by helieal tomotherapy. The setup errors were evaluated by online correction through registering the MVCT images to the planning CT images. Results The mean setup error values on right-left (X) , superior-inferior ( Y), anterior-posterior (Z) , pitch, roll and taw directions were X ( - 0.88 ± 2.37 ) mm, Y ( - 1.18 ±2.82 ) mm, Z ( 1.41 ±1.82) mm, Pitch ( 0.15 ± 0.54 )°, Roll ( 0.27± 0.96 )° and Yaw ( 0.01 ± 0.52 )°. The planning target volume (PTV) margin from clinical target volume (CTV) were 3.42 mm,4.33 mm and 4.09 mm in X,Y and Z axes,respectively. Conclusion MVCT image guided radiotherapy may improve the setup precision of intensity-modulated radiotherapy (IMRT) and ensure more precise dose delivery and less normal tissue complications.
Keywords:head and neck neoplasms/radiotherapy  tomography  spiral computed  image processing  computer-assisted  posture  radiotherapy/methods
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