蛋白质组学与器官移植

：随着质谱仪器、蛋白质和肽段的分离技术及数据分析工具的发展，不同组织、器官或细胞的蛋白质表达谱的研究也得到了迅速发展。蛋白质组学最基本的目的就是定性和定量地鉴定一个细胞或组织中的全部蛋白质。因此，如何充分利用质谱数据对蛋白质组学研究的意义很大。近几年，蛋白质组学已开始被应用到器官移植的同种异体排斥反应以及排异反应相关生物标记物的发现等领域。通过这一技术在器官移植中的广泛应用，可以早期发现及处理移植物的排异。因此，蛋白质组学的研究在器官移植排斥反应的诊断中将具有潜在的应用前景。

Proteomics and organ transplantation

With the development of mass spectrometer, protein and peptide separation technology, and data analysis tools, the study on protein expression profiling of various tissues, organs or cells has been developed rapidly. The most basic purpose of proteomics is qualitative and quantitative identification of the whole protein in a cell or tissue. Therefore, how to make full use of mass spectrometry data has an important significance in proteome. Recently years, proteomics has begun to be applied in allograft rejection and discovery of rejection related biomarkers in organ transplantation. Through the extensive application of the technology in organ transplantation, graft rejection can be earlier detection and treatment. Therefore, the proteomics research have potential application prospects in the diagnosis of the organ transplant rejection.