被动吸烟母血及脐血一氧化氮水平及其影响

目的 :探讨被动吸烟母血及脐血中一氧化氮 (NO)水平和胎儿发育的关系。方法 :采用分光光度法测定 38例被动吸烟孕妇 (A组 )及 30例正常妊娠孕妇 (B组 )分娩时的母血及脐血 NO水平。结果 :A组母血及脐血 NO含量显著低于 B组 (P<0 .0 5 ,P<0 .0 1) ;两组脐血 NO水平均高于母血 (P<0 .0 1,P<0 .0 5 ) ;两组母血及脐血中 NO均有相关性 (r=0 .5 4 75 ,r=0 .85 0 6 ) ;两组小于胎龄儿 (SGA)发生率和新生儿体重均有显著差异 (P<0 .0 5 )。结论 :被动吸烟能降低母血及脐血 NO水平 ,而这种水平的变化可能影响低体重儿的发生率和新生儿体重

The levels of maternal and umbilical serum nitric oxide in passive smoking pregnant women and its effect

Objective:To study the relation between fetal growth and levels of maternal and umbilical serum nitric oxide(S-NO) caused by passive smoking.Methods:The levels of maternal and umbilical S-NO was assaged by spectrophotlmety 38 patients with passive smoking pregnant women(A group).30 patients with normal pregnant women (B group) in their trimester.Results:Contents of S-NO maternal and umbilical in A group was significantly lower than that in B group( P <0.05, P <0.01);S-NO levels of umbilical cord was higher than that of maternal srum in both groups( P <0.01, P <0.05).There was correlation about S-NO concentration between mother and her fetus in both groups(r=0.5475,r=0.8506).The incidences of low birth weigh infant(LBW) and the weight of the newborn there were statistically significant in both groups ( P <0.05, P <0.05).Conclusion:Passive smoking could decrease levels of maternal and umbilical S NO,and the changes of the levels could relate to the incidences of small for gestational age infant(SGA) and the weight of the newborn.