| ~(131)I标记单克隆抗体在裸小鼠肠癌模型中的放射免疫显象研究 |
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| 引用本文： | 张洁,王才力,孙去病,潘爱艮,陈素农,刘长庚,陈玉华.~(131)I标记单克隆抗体在裸小鼠肠癌模型中的放射免疫显象研究[J].中南大学学报(医学版),1990(3). |
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| 作者姓名： | 张洁 王才力 孙去病 潘爱艮 陈素农 刘长庚 陈玉华 |
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| 作者单位： | 湖南医科大学肿瘤研究所免疫生物学研究室
(张洁，王才力，孙去病)，湖南医科大学第一附属医院同位素科
(潘爱艮，陈素农，刘长庚)，湖南医科大学第一附属医院同位素科(陈玉华) |
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| 基金项目： | 国家“七·五”攻关资助课题 |
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| 摘 要： | 应用~(131)I标记抗大肠癌单克隆抗体Hb_3静脉或腹腔注入裸小鼠人肠癌模型体内,进行生物学分布和显象研究。除移植瘤直径小于0.5cm的裸小鼠外,48h即可查见良好的肿瘤显象,72、96h更为清晰。肿瘤与肌肉、肠道的每mg组织的放射性浓度之比均大于2,以96h最高,分别是6.9和14.1。
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| 关 键 词： | 放射免疫测定 放射性核素成象 抗体 单克隆 大肠肿瘤 碘同位素 小鼠 裸 |
RADIOIMMUNOIMAGING STUDY WITH 131I-LABELED ANTI- COLORECTAL CARCINOMA MONOCLONAL ANTIBODY IN NUDE MOUSE MODEL |
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| Zhang Jie Wang Caili Sun Quibing.RADIOIMMUNOIMAGING STUDY WITH 131I-LABELED ANTI- COLORECTAL CARCINOMA MONOCLONAL ANTIBODY IN NUDE MOUSE MODEL[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1990(3). |
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| Authors: | Zhang Jie Wang Caili Sun Quibing |
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| Institution: | Zhang Jie Wang Caili Sun QuibingDepartment of Immunobiology. Cancer Research Institute,Hunan Medical Universil yPan Aigin Chen Sunong Liu Changgeng Chen YuhuaDepartment of Nuclear Medicine,The First Affiliated Hospi t al Hunan Medical University |
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| Abstract: | Inorder to study the biological distribution and radioimmunoimage of 131I- labeled anti-colorectal carcinoma antibody Hb3 nude mice bearing human HRT-18 colorectal cancer cell line were given by i. v. or i. p. injections of isotope-labeled antibody. Good images of the tumor xenografts were obtained at 48th hour after injection. The positive rate was 92 percent. The ratio of T/NT of tumor to muscle and tumor to intestine were 2, and approached their highest levels to 6.9 and 14.1 respectively at 96th hour after injection. These results indicated promise of monoclonal antibody Hb3 in the directed diagnosis and therapy of human colorectal cancer. |
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| Keywords: | radioimmunoassay antibodies monoclonal colonic neoplasms iodine isotopes mice nude radionuclide imaging |
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