New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778 |
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Authors: | Uchida Ryuji Imasato Rie Yamaguchi Yuichi Masuma Rokuro Shiomi Kazuro Tomoda Hiroshi Omura Satoshi |
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Institution: | The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 1088641, Japan. |
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Abstract: | Four new antibiotics, sesquicillins B to E were isolated from the culture broth of Albophoma sp. FKI-1778 together with known sesquicillin (sesquicillin A in this paper). The structures of sesquicillins were elucidated by spectroscopic studies including various NMR experiments. All sesquicillins have a common pyrano-diterpene skeleton. Sesquicillins showed moderate inhibitory activity against the growth of Artemia salina (brine shrimps) and Jurkat cells. |
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