银杏叶提取物对急性脑梗塞患者内皮细胞的保护作用

目的 :观察银杏叶提取物 (杏丁 )对急性脑梗塞患者血浆 von Willebrand因子 (v WF)和血栓调节蛋白(TM)的影响 ,从而了解其对内皮细胞的保护作用。方法 :34例急性脑梗塞患者随机分为两组 :实验组 ,n=17,每日静脉滴杏丁 2 0 ml,连续 14 d;对照组 ,n=17,每日静脉滴注复方丹参注射液 2 5 0 ml,于治疗前、治疗后 7d、 14 d检测两组患者血浆 v WF和 TM的水平变化。结果 :两组患者血浆 v WF和 TM治疗前均无显著性差异 (P>0 .0 5 ) ,治疗后第 7d、14 d实验组 v WF明显低于对照组 (P<0 .0 5 ) ,且两组患者治疗后均低于治疗前 ((P<0 .0 5或 P<0 .0 1) ;治疗后第 7d实验组 TM明显高于对照组 (P<0 .0 5 ) ,且两组患者治疗后均高于治疗前 (P<0 .0 5或 P<0 .0 1)。结论 :银杏叶提取物(杏丁 )可明显降低急性脑梗塞患者血浆 v WF和提高 TM水平 ,有益于保护内皮细胞的功能

Protection of Ginkgo biloba extract on endothelial cell at acute cerebral infarct patients

Objective: To investigate the effects of Ginkgo biloba extract (Xingding) on treatment of acute cerebral infarct for plasmatic von Willebrand factor (vWF) and thrombomodulin (TM). Methods: 17cases with acute cerebral infarct patients wer selected randomly and treated with Xinding of 20ml for intravenous drip; another 17 cases were selected as control group and treated with compound salvia miltiorrhiza of 250ml for intravenous drip. The treatment for both groups was a forteen-day course of one dose a day. All of patients were tested for plasmatic vWF and TM. Results: there ans no obvious difference of changes in plasmatic vWF and TM on treatment before ( P>0.05 ), but the vWF was significantly difference on the seventh day and the fourteenth day between the both groups( P<0.05 ); the plasmatic TM was significantly difference on the seventh day between the both groups( P<0.05 ). Conclusion: Ginkgo biloba extract (Xinding) has a good and safe therapeatic effect on protect endothelial cells of treating acute cerebral infarction patients than compound salvia miltiorrhiza.