实验性视网膜光性损伤

我们用Wister大鼠建立了视网膜急性光性损伤实验模型．动物在全麻下照光(白光)lh，照度为20 0001x．分别于照光后24、48h，1、2、3、4、5周处死实验动物。病理组织学显示视网膜急性光性损伤始于光感受器外节，表现为碎解和消失，随之波及内节和视网膜色素上皮(RFE)，部分标本外核层亦波及。后期(照光后2-3周)有些标本显示内、外节有某种程度修复，另一些标本则无。有一个照光后5周的标本显示外核层，内、外节完全消失。所有标本未显示任何炎症反应，提示视网膜急性光性损伤是一个退行性变性过程。（中华眼底病杂志，1994，10：84-85）

EXPERIMENTAL RETINAL PHOTIC INJURY

An experimental model of retinal acute photic injury was developed in Wister rats. Aninmls were exposed to white light in intensity of 20 000 lux under general anesthesia for 1 hr. Two rats were sacrificed at 24, 48hr, day 7, 14,21,28,35 after li$ht exposure respectively. The histopathologic study showed that the retinal acute photic injury initiated in the outer seSment characterized by disorganization and loss of the outer segment at the early stage, and then the inner segment and RPE were involved. The decrease of the thickness of the outer nuclear layer was seen in a few of our cases.Some of our samples showed recovery of the outer and inner segment from the light damage of certian degrees 2 or 3 weeks after light exposure, but others did not. One sample from 5 weeks after light exposure demonstrated that the outer nuclear layer, the outer and inner segment completely lost. Thcinflammatory responses were not observed in all of our samples inplicating that the retinal acute photic damage is a degeneration process.（Chin J Ocul Fundus Dis,1994,10:84-85）