尼莫地平对脑出血患者血清NSE影响的临床研究

目的：探讨脑出血后患者血清神经元特异性烯醇化酶（NSE）变化以及尼莫地平治疗对患者血清NSE的影响。方法：60例脑出血患者随机分为尼莫地平组与常规治疗组，每组30例。在治疗前后测定血清NSE水平。结果：尼莫地平组和常规治疗组治疗前血清NSE水平均显著高于正常对照组；治疗后明显下降，血清NSE值尼莫地平组明显高于常规治疗组（P〈0．01）。结论：脑出血患者血清NSE水平显著升高。尼莫地平治疗后明显下降。

Study on Effect of Nimodepine on the Changes of Serum NSE Levels in Patients with Acute Cerebral Hemorrhage

Objective To investigate the changes of serum NSE levels in patients with acute cerebral hemorrhage and the effect of nimodepine treatment.Methods Serum neuron specific enolase(NSE) levels were measured with CLIA in 60 patients with cerebral hemorrhage both before and after treatment as well as in 30 controls.Half of the patients(n=30) were treated with nimodepine and the ther half were not.Results In all the 60 patients,serum NSE levels were significantly higher than those in controls(P<0.01).After treatment,the NSE levels dropped markedly in all the patients.However,the decrease in the patient group treated with nimodepine was significantly than that in the patient group treated without nimodepine(P<0.01).Conclusion Nimodepine treatment is efficient for reducing the serum NSE levels,which may be related to the residual hematoma size.