Typing an Unrelated Panel with PLT Cells: Association with DW Clusters |
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| Authors: | B J ALTER F H BACH S JARAMILLO P WERNET |
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| Institution: | Immunobiology Research Center and Departments of Medical Genetics and Surgery, The University of Wisconsin, Madison, Wisconsin, USA, and Immunohematology and Histocompatibility Laboratory, Department of Internal Medicine, University of Tübingen, Tübingen, West Germany |
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| Abstract: | Primed LD typing (PLT) cells prepared in one Laboratory (Madison) were shipped in the frozen state and tested in Tübingen on a separate panel that had been typed with homozygous typing cells. Those PLT cells that had been grouped, on the basis of their reaction with test cells of the Madison panel, as defining an HLA PL antigen showed identical or nearly identical patterns of reactivity with the Tübingen panel. Clear association between certain PL antigens and DW clusters as defined with homozygous typing cells could be demonstrated. Of particular interest may be combinations of certain PLT reactions with D-locus-typed cells, where the primed cells do not react as expected from the target's HLA-D type. |
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