冠状动脉粥样硬化斑块消退研究进展

冠状动脉粥样硬化的发生与低密度脂蛋白及炎症反应、内皮功能减退等有关。近年来多项临床试验证实早期强化应用他汀类药物可以通过降低低密度脂蛋白、抗炎、改善内皮功能等途径改善急性冠脉综合征患者的预后。其中他汀类药物发挥的抗炎症反应、改善内皮功能等多效性作用日益受到重视。而应用血管内超声的研究发现强化他汀类治疗能够显著遏制甚至消退冠状动脉粥样斑块。

Advances in Research into Coronary Artery Atherosclerotic Plaque Regression

The development of coronary artery atherosclerosis contributes to high levels of low-density lipoprotein, inflammation, and endothelial dysfunction, as well as to other conditions. Recent clinical trials have demonstrated that the administration of statins could improve prognosis of acute coronary syndrome thanks to lowering of lipid levels, anti-inflammation and enhancing endothelial function. The pleiotropy of statins has been a recent focus of research attention. It has been confirmed by intravascular ultrasound that therapy involving high doses of statins promotes the regression of atherosclerotic plaque.