| 运动对大鼠胸主动脉损伤后c-myc、c-fos和p53表达的影响 |
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| 引用本文： | 殷松楼,张宝慧. 运动对大鼠胸主动脉损伤后c-myc、c-fos和p53表达的影响[J]. 中国运动医学杂志, 1999, 18(1): 3 |
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| 作者姓名： | 殷松楼 张宝慧 |
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| 作者单位： | 1. 江苏省徐州医学院附属医院内分泌科,221002
2. 北京医科大学第三医院康复医学中心 |
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| 摘 要： | 采用原位杂交方法分析了大鼠胸主动脉损伤后原癌基因ｃ ｍｙｃ、ｃ ｆｏｓ和抗癌基因ｐ５３表达情况，并观察运动对其影响。结果表明：动脉损伤后ｃ ｆｏｓ、ｃ ｍｙｃ表达明显增加，ｐ５３表达下降；运动组ｃ ｆｏｓ和ｃ ｍｙｃ明显被控制，ｐ５３表达增强。研究结果提示运动对纠正原癌基因和抗癌基因表达失衡有作用，为运动防治平滑肌细胞过度增殖性疾病的分子生物学机制研究提供了线索
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| 关 键 词： | 运动 大鼠 胸主动脉损伤 原癌基因 抗癌基因 |
Exercise Effects on Expression of c-fos, c-myc and p53 in Rats after Thoracic Aorta Injury |
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| Yin Songlou,Zhan Baohui. Exercise Effects on Expression of c-fos, c-myc and p53 in Rats after Thoracic Aorta Injury[J]. Chinese Journal of Sports Medicine, 1999, 18(1): 3 |
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| Authors: | Yin Songlou Zhan Baohui |
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| Abstract: | Expression of proto_oncogene c_fos,c_myc and anti_oncogene p53 were analysed in situ in rats after thoracic aorta injury,and effects of exercise on the expression of c_fos,c_myc and p53 were observed. The results showed that the expression of c_fos and c_myc evidently increased and the expression of p53 decreased after artery injury.Expression of c_fos and c_myc were inhibited and expression of p53 was enhanced in the exercise group.The results suggested that exercise could correct unbalance of expression between proto_oncogene and anti_oncogene which might be the important molecular biologic mechanism of preventing and treating the diseases with SMC over_proliferation through exercise. |
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| Keywords: | exercise rats aorta injury proto_oncogeme anti_oncogene |
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