Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study |
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Authors: | Lehto Soili M Tolmunen Tommi Kuikka Jyrki Valkonen-Korhonen Minna Joensuu Mikko Saarinen Pirjo I Vanninen Ritva Ahola Pasi Tiihonen Jari Lehtonen Johannes |
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Affiliation: | Department of Psychiatry, Kuopio University Hospital, 70210 Kuopio, Finland. Soili.Lehto@kuh.fi |
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Abstract: | Data on neurobiological differences between major depression (MD) and double depression (DD) are scarce. We examined the striatum dopamine (DAT) and midbrain serotonin transporter (SERT) binding of [123I] nor-β-CIT in DD patients (n = 8) and compared it to that in MD patients (n = 11) and healthy controls (n = 19). Drug-naïve patients and controls were imaged by single-photon emission computed tomography at baseline, and the patients also after one year of psychodynamic psychotherapy. Both DD and MD groups had lower midbrain [123I] nor-β-CIT binding compared with the controls. Baseline 17-item Hamilton Depression Rating Scale (HAM-D-17) scores significantly decreased in both groups after one year of psychotherapy (DD: t = 3.55, p = 0.009; MD: t = 5.86, p < 0.001). No differences between the DD and MD groups were observed in age-adjusted baseline striatum or midbrain [123I] nor-β-CIT binding or its change during psychotherapy. Age-adjusted baseline striatum [123I] nor-β-CIT binding correlated inversely with the duration of both dysthymia (rho = −0.76, p = 0.03) and MD (rho = −0.83, p = 0.01) in the DD group. No such finding was observed in the MD group (rho = 0.26, p = 0.44). Baseline HAM-D-17 did not correlate with the change in striatum or midbrain [123I] nor-β-CIT binding in either group. In conclusion, our findings suggest that when using midbrain [123I] nor-β-CIT binding as a marker of SERT binding, no differences are detectable between patients with DD and MD. However, low striatum [123I] nor-β-CIT binding, a marker of DAT binding, may be associated with a longer illness duration in dysthymia. |
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Keywords: | DAT Double depression Dysthymia Psychotherapy SERT SPECT |
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