| 沈阳地区人群TCF7L2基因rs7903146-T/C多态性与2型糖尿病的相关性 |
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| 引用本文： | 张晓蕾,王玉霞,刘巍,边澈,纪红梅.沈阳地区人群TCF7L2基因rs7903146-T/C多态性与2型糖尿病的相关性[J].中国误诊学杂志,2012,12(2):255-256. |
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| 作者姓名： | 张晓蕾 王玉霞 刘巍 边澈 纪红梅 |
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| 作者单位： | 中国医科大学附属第四医院内分泌科,辽宁沈阳,110032 |
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| 基金项目： | 辽宁省教育厅科学技术研究项目(2009A772) |
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| 摘 要： | 目的 探讨沈阳地区汉族人群TCF7L2基因rs7903146多态性与2型糖尿病的相关性.方法 采用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP),对203例正常个体和202例2型糖尿病患者TCF7L2基因rs7903146多态位点进行检测.结果 rs7903146的等位基因T在对照组与病例组的频率分别为2.96％和7.18％,两者之间差异有统计学意义(P＜0.05).结论 沈阳地区汉族人群TCF7L2基因rs7903146位点的多态性与2型糖尿病可能具有相关性.
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| 关 键 词： | 糖尿病 2型/遗传学 多态现象 遗传 |
Relationship between rs7903146-T/C polymorphism of TCF7L2 Gene and Type 2 Diabetes in Shenyang Population |
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| ZHANG Xiao-lei
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WANG Yu-xia
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LIU Wei
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Bian Che
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JI Hong-mei.Relationship between rs7903146-T/C polymorphism of TCF7L2 Gene and Type 2 Diabetes in Shenyang Population[J].Chinese Journal of Misdiagnostics,2012,12(2):255-256. |
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| Authors: | ZHANG Xiao-lei WANG Yu-xia LIU Wei Bian Che JI Hong-mei |
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| Institution: | Department of Endocrinology,The Forth Affiliated Hospital of China Medical University,Shenyang 110032,China |
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| Abstract: | Objective To study the relationship between the rs7903146-T/C polymorphism of TCF7L2 gene and Type 2 diabetes in Han population of shenyang.Methods The rs7903146-T/C polymorphism was detected in 203 healthy Han controls and 202 patients with Type 2 diabetes by using PCR-RFLP method.Results The allele frequency T of rs7903146 in control groups and the case were 5.91% and 14.36% respectively(P<0.05).There was a statistical difference between the two groups.Conclusion The rs7903146-T/C polymorphism of TCF7L2 maybe associate with Type 2 diabetes in Shenyang Han population. |
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| Keywords: | Diabetes Mellitus Type 2/genetics Polymorphism Genetic |
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