| MicroRNA及其在子痫前期中的作用研究进展 |
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| 引用本文： | 于祥远,刘合焜. MicroRNA及其在子痫前期中的作用研究进展[J]. 中国优生与遗传杂志, 2012, 0(5): 7-9 |
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| 作者姓名： | 于祥远 刘合焜 |
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| 作者单位： | 福建医科大学基础医学院细胞生物学与遗传学系;神经生物学研究中心 |
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| 摘 要： | 近年来有研究发现一些miRNAs在子痫前期患者的胎盘与正常妊娠胎盘组织中的表达存在显著性差异,推测miRNAs可能在胎盘生长发育过程中发挥了一定的作用,其失衡表达可能参与了子痫前期的发病过程。血清或血浆等体液中稳定存在的miRNAs有望作为妊娠性疾病早期预警诊断的理想的、潜在分子标记,而针对miRNAs设计分子靶向药物的探索为揭示子痫前期发病的机理、制定有效的个体化治疗方案具有重要意义。本文即对有关miRNAs及其在子痫前期发病中的最新研究进展作一综述。
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| 关 键 词： | microRNA 子痫前期 生物学标记 分子靶向药物 |
Advances of microRNAs researches in preeclampsia |
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| YU Xiang-yuan,LIU He-. Advances of microRNAs researches in preeclampsia[J]. Chinese Journal of Birth Health & Heredity, 2012, 0(5): 7-9 |
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| Authors: | YU Xiang-yuan LIU He- |
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| Affiliation: | kun2.(Department of Cell Biology and Genetics1,2;Neurobiology Research Center1,Fujian Medical University,Fuzhou 350004,China) |
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| Abstract: | In recent years,miRNAs have been found a signicantly differential expression profiles in human placentas between pre-eclamptic and normal pregnancies.The deregulated miRNAs may be involvement in the pathogenesis of pre-eclampsia.The stable existent miRNAs in serum and other body fluids called circulating miRNAs,are likely to be an potential and ideal biomarkers.To develop miRNAs molecular targeted drugs may help reveal the pathogenesis of pre-eclampsia and make effective individualized treatment plans.This paper will give a review about the latest studies on miRNAs in the pathogenesis of pre-eclampsia. |
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| Keywords: | microRNA Pre-eclampsia Biomarkers Molecular targeted drugs |
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