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| 杜仲不同提取部位对离体血管舒张作用的研究 | |
| 引用本文： | 王虹,瞿晶田,赵鑫,郭英,刘二伟.杜仲不同提取部位对离体血管舒张作用的研究[J].天津中医药,2012,29(4):381-383. |
| 作者姓名： | 王虹 瞿晶田 赵鑫 郭英 刘二伟 |
| 作者单位： | 1. 天津中医药大学,天津市现代中药重点实验室,天津300193;天津中医药大学,天津市中药药理学重点实验室,天津300193 2. 天津中医药大学,天津市现代中药重点实验室,天津300193 3. 天津中医药大学,天津市中药药理学重点实验室,天津300193 |
| 基金项目： | 天津市应用基础及前沿技术研究计划项目，国家自然科学基金面上项目 |
| 摘 要： | 目的]寻找杜仲中具有血管舒张作用的提取部位。方法]分离得到杜仲11个提取部位,采用大鼠胸主动脉环实验观察各提取部位的血管舒张作用。结果]在11个组分中只有组分6和11(终浓度0.4,0.8,1.2,1.6,2.0 mg/mL)可浓度依赖性舒张去甲肾上腺素收缩的离体血管。结论]杜仲提取部位6和11富含杜仲中舒张血管的有效成分。 |
| 关 键 词： | 杜仲 提取部位 血管舒张 |
| 收稿时间： | 2012/3/28 0:00:00 |
Effects of fractions at different part of Eucommia ulmoides on the vascular relaxation in vitro |
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| WANG Hong,QU Jing-tian,ZHAO Xin,GUO Ying and LIU Er-wei.Effects of fractions at different part of Eucommia ulmoides on the vascular relaxation in vitro[J].Tianjin Journal of Traditional Chin Medicine,2012,29(4):381-383. | |
| Authors: | WANG Hong QU Jing-tian ZHAO Xin GUO Ying and LIU Er-wei |
| Institution: | 1(1.Tianjin Key Laboratory of Modern Chinese Medicine,Tianjin University of TCM,Tianjin 300193,China; 2.Tianjin Key Laboratory of Chinese Medical Pharmacology,Tianjin University of TCM,Tianjin 300193,China) |
| Abstract: | Objective] To find out the fraction of Eucommia ulmoides possessing the best effect of vascular relaxation Methods] The aortic ring of rats was used as the experiment model to investigate the vascular relaxation effect of different fractions in Eucommia ulmoides. Result] The fraction 6 and 11(final concentration 0.4, 0.8, 1.2, 1.6, 2.0 mg/mL) showed a good vasodilation effect in aortic rings precontracted with norepinephrine. Conclusion] Fraction 6 and 11 enrich the constituents which has good vasodilation effect in Eucommia ulmoides. |
| Keywords: | Eucommia ulmoides constituents vasodilation |
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