| 骨碎补外用对环磷酰胺致小鼠斑秃模型的影响 |
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| 引用本文： | 黄云英,张德芹,沈丽,王雪妮,杜娟,王元元.骨碎补外用对环磷酰胺致小鼠斑秃模型的影响[J].天津中医药,2012,29(4):375-377. |
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| 作者姓名： | 黄云英 张德芹 沈丽 王雪妮 杜娟 王元元 |
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| 作者单位： | 天津中医药大学中医药研究院,方剂学教育部重点实验室,天津300193 |
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| 摘 要： | 目的]考察骨碎补外用对环磷酰胺致C57BL/6小鼠斑秃模型的影响。方法]采用环磷酰胺腹腔注射建立C57BL/6小鼠斑秃模型,观察骨碎补外用对小鼠毛囊组织学变化和血清细胞间黏附蛋白(ICAM-1)、内皮细胞-白细胞黏附分子-1(ELAM-1)水平的影响。结果]骨碎补外用能使实验性斑秃模型小鼠血清ICAM-1和ELAM-1水平降低,毛囊数增多(P<0.05或P<0.01)。结论]骨碎补外用能够抑制毛囊进入退行期,对斑秃模型小鼠具有治疗作用。
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| 关 键 词： | 骨碎补 外用 环磷酰胺 斑秃 |
| 收稿时间： | 2012/2/10 0:00:00 |
Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice |
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| HUANG Yun-ying,ZHANG De-qin,SHEN Li,WANG Xue-ni,DU Juan and WANG Yuan-yuan.Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice[J].Tianjin Journal of Traditional Chin Medicine,2012,29(4):375-377. |
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| Authors: | HUANG Yun-ying ZHANG De-qin SHEN Li WANG Xue-ni DU Juan and WANG Yuan-yuan |
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| Institution: | (Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193,China) |
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| Abstract: | Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in C57BL/6 mice. Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. Results] The levels of ICAM-1 and ELAM-1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application. |
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| Keywords: | Drynaria fortunei external application cyclophosphamide alopecia areata |
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