| 肢体缺血预处理对心肌的保护作用 |
| |
| 引用本文： | 武旭东,刘秀华,徐成斌. 肢体缺血预处理对心肌的保护作用[J]. 军医进修学院学报, 1999, 20(3): 235-236 |
| |
| 作者姓名： | 武旭东 刘秀华 徐成斌 |
| |
| 作者单位： | [1]解放军总医院老年心血管病研究所 [2]北京医科大学人民医院 |
| |
| 摘 要： | 目的：观察肢体缺血预处理（ＩＰＣ）对心脏缺血／再灌注（Ｉ／Ｒ）损伤的影响。方法：对家兔股以复短暂夹闭与开放进行ＩＰＣ，然后复制在体心脏Ｉ／Ｒ模型，观察肢体ＩＰＣ对于皇续长期Ｉ／Ｒ损伤所致心肌细胞乳酸氢酶（ＬＤＨ）漏出和心肌梗面积的影响，并与相应的心脏ＩＰＣ组时间比较。结果：肢体缺血预处理明显缩小民梗互面积，减少心肌组织乳酸脱氢酶漏出，与心脏ＩＰＣ组之间差异无统计学意义。结论：肢体缺血预处理对Ｉ／Ｒ
|
| 关 键 词： | 预处理 肢体缺血 心肌缺血 再灌注损伤 |
The protective effects of limb ischemic preconditioning on rabbit heart |
| |
| Wu Xudong,Liu Xiuhua,Xu Chengbin. The protective effects of limb ischemic preconditioning on rabbit heart[J]. Academic Journal of Pla Postgraduate Medical School, 1999, 20(3): 235-236 |
| |
| Authors: | Wu Xudong Liu Xiuhua Xu Chengbin |
| |
| Abstract: | Objective:To observe the effects of limb ischemic preconditioning (IPC) on ischemia/reperfusion (I/R) injury of rabbit heart.Methods: On the model of in vivo rabbit heart subjected to I/R, IPC was performed by transient occluding the femoral arteries for 5 min followed by reperfusion for 5 min three times prior to I/R. The effects of IPC on lactatic dehydrogenase (LDH) releasine and myocardial infarction size induced by I/R were measured, and compared with the results of heart IPC Only.Results: Both limb and heart preconditioning significantly reduced myocadial infarct size and leakage of LDH ( P <0 01). Conclusion:Limb IPC has a protective effect on myocardial infarct size induced by I/R. The protective effectiveness is similar to that of heart ischemic preconditioning. |
| |
| Keywords: | limb heart preconditioning |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
