| HPLC法测定盐酸头孢吡肟中的有机残留量N-甲基吡咯烷 |
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| 引用本文： | 郑丽芬. HPLC法测定盐酸头孢吡肟中的有机残留量N-甲基吡咯烷[J]. 抗感染药学, 2004, 1(1): 29-30 |
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| 作者姓名： | 郑丽芬 |
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| 作者单位： | 浙江康乐药业有限公司,浙江,温州,325028 |
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| 摘 要： | 目的:建立盐酸头孢吡肟原料中N-甲基吡咯烷有机残留量的测定方法。方法:高效液相法,Spherisorb SCX色谱柱(4.6×50mm),流动相0.3％稀硝酸-乙睛(60:40),流速1.5mL·min-1,柱温45℃,Waters 430电导检测器。结果:本方法线性范围12.49～124.90μg·mL-1(r=0.9993,n=6),最低检测量12.49μg·mL-1,平均回收率99.31％。结论:本方法操作简便,准确有效。
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| 关 键 词： | 高效液相法 电导检测器 盐酸头孢吡肟 N-甲基吡略烷 |
| 文章编号： | 1672-7878(2004)01-0029-02 |
Determination the contents of residual volatile organic solvents of N-Methyl-pyrrolidine in Cefepime dihydrochloride by HPLC |
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| Zheng Li-feng. Determination the contents of residual volatile organic solvents of N-Methyl-pyrrolidine in Cefepime dihydrochloride by HPLC[J]. Anti-infection Pharmacy, 2004, 1(1): 29-30 |
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| Authors: | Zheng Li-feng |
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| Abstract: | Objective: To determine the contents of residual volatile organic solvents of N-Methylpyrrolidine in Cefepime dihydrochloride by HPLC. Methods: HPLC method was developed. The waters 430 conductivity detector and a pherisorb SCX colume (4.6 × 50mm) was used with the mobile phase of 0.3% dilute nitric acid -acetonitrile.The flow rate was 1.5mL . min and the column temperature was45℃. Results: The linearrange was 12.49-124.9μ g . mL (r = 0.9993, n = 6) , The LOD is 12.49μ g. mL .The average recoveries was 99.31%. Conclusion: The method was simple and accurate. |
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| Keywords: | HPLC Conductivity detector Cefepime dihydrochloride N-Methylpyrrolidine |
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