丹参川芎嗪联合前列地尔治疗后循环缺血性眩晕临床研究

目的:观察丹参川芎嗪联合前列地尔治疗后循环缺血性眩晕的效果及对患者血液动力学和血液流变学的影响.方法:选取110例后循环缺血性眩晕患者,按随机数字表法分为对照组和研究组各55例.对照组给予神经内科常规药物治疗,研究组在对照组基础上给予丹参川芎嗪联合前列地尔治疗.比较2组临床疗效,检测血液动力学指标[基底动脉(BA)、左...

Clinical Study on Danshen Chuanxiongqin Combined with Alprostadil for PosteriorCirculation Ischemic Vertigo

Objective:To observe the curative effect of Danshen Chuanxiongqin combined with alprostadil for posterior circulation ischemic vertigo and its effect on hemodynamics and hemorheology. Methods: A total of 110 cases of patients with posterior circulation ischemic vertigo were selected and divided into the control group and the study group according to the random number table method, 55 cases in each group. The control group was given routine medicine treatment of neurology, and the study group was additionally given Danshen Chuanxiongqin combined with alprostadil based on the treatment of the control group. The clinical effect was compared between the two groups. The differences in the hemodynamics indexes [blood flow velocity of basilar artery(BA),left vertebral artery(LVA),right vertebral artery(RVA),and resistance index(RI)],the hemodynamics indexes [plasma viscosity(PV),packet cell volume(PCV),whole blood viscosity at low shear and high shear], indexes of blood coagulation function [fibrinogen(FIB), prothrombin time(PT), and activated partial thromboplastin time(APTT), and the serum indexes [endothelin-1(ET-1), calcitonin gene-related peptide(CGRP),and the ratio of ET-1 to CGRP] were detected. Dizziness Handicap Inventory-Screening(DHI-S) and Dizziness Assessment Rating Scale(DARS) were applied to evaluating the vertigo symptoms in the two groups. Results: The elimination time of nausea and vomiting,vertigo and headache,ataxia,and disequilibrium in the study group was earlier than that in the control group,differences being significant(P<0.05). After treatment,blood flow velocity of BA,LVA,and RVA in the two groups were significantly increased when compared with those before treatment,and RI was significantly decreased;each index above in the study group was better than that in the control group,differences being significant(P<0.05). After treatment,PV,PCV,and whole blood viscosity at low shear and high shear in the two groups were decreased when compared with those before treatment, and the four indexes above in the study group were lower than those in the control group,differences being significant(P<0.05). After treatment, levels of PT and APTT in the two groups were increased when compared with those before treatment,and FIB was decreased;each index above in the study group was better than that in the control group, differences being significant(P<0.05). After treatment, ET-1 and ET-1/CGRP in the two groups were significantly decreased when compared with those before treatment, and CGRP was significantly increased;each index above in the study group was significantly better than that in the control group,differences being significant(P<0.05). After treatment, scores of DHI-S and DARS in the two groups were significantly decreased when compared with those before treatment,and the two scores in the study group were lower than those in the control group,differences being significant(P<0.05). Conclusion: In the treatment of posterior circulation ischemic vertigo, the therapy of Danshen Chuanxiongqin combined with alprostadil can promote rapid outcome of clinical symptoms,improve hemodynamics,hemorheology,and blood coagulation function,with high clinical safety.