| 环状RNA与神经、肌肉功能及相关疾病的研究进展 |
| |
| 引用本文： | 高轶昳,刘菲,黄卫,于阅尽,周义德,陈世彩,郑宏良,蒋昕怡.环状RNA与神经、肌肉功能及相关疾病的研究进展[J].第二军医大学学报,2021,42(3):301-307. |
| |
| 作者姓名： | 高轶昳 刘菲 黄卫 于阅尽 周义德 陈世彩 郑宏良 蒋昕怡 |
| |
| 作者单位： | 海军军医大学(第二军医大学)长海医院耳鼻咽喉科,上海 200433;上海中医药大学附属第七人民医院耳鼻咽喉科,上海 200137;海军军医大学(第二军医大学)长海医院耳鼻咽喉科,上海 200433;上海中医药大学附属第七人民医院耳鼻咽喉科,上海 200137;上海市宝山区仁和医院口腔科,上海 200431 |
| |
| 基金项目： | 国家自然科学(8170040837). National Natural Science Foundation of China (8170040837) |
| |
| 摘 要： | 晚期声带麻痹喉肌功能损伤是咽喉外科亟待解决的难题.环状RNA(circRNA)是通过非经典剪接方式形成的一种内源性环形非编码RNA,它可能通过miRNA海绵、可变剪接调节因子等方式在多种疾病的发生、发展中起重要作用,是潜在的疾病早期诊断生物标志物或干预治疗的新靶点.随着研究的不断深入,circRNA与神经、肌肉功能及相...
|
| 关 键 词： | 环状RNA 神经系统疾病 神经损伤 肌肉相关疾病 |
| 收稿时间： | 2020/8/21 0:00:00 |
| 修稿时间： | 2021/1/14 0:00:00 |
Circular RNA and nerve, muscle functions and related diseases: research progress |
| |
| GAO Yi-yi,LIU Fei,HUANG Wei,YU Yue-jin,ZHOU Yi-de,CHEN Shi-cai,ZHENG Hong-liang,JIANG Xin-yi.Circular RNA and nerve, muscle functions and related diseases: research progress[J].Academic Journal of Second Military Medical University,2021,42(3):301-307. |
| |
| Authors: | GAO Yi-yi LIU Fei HUANG Wei YU Yue-jin ZHOU Yi-de CHEN Shi-cai ZHENG Hong-liang JIANG Xin-yi |
| |
| Institution: | The seventh people''s hospital affiliated to Shanghai university of traditional Chinese medicine,Department of Otolaryngology, Changhai Hospital, Naval Military Medical University,,,,,, |
| |
| Abstract: | Laryngeal muscle function impairment caused by advanced vocal fold paralysis is an urgent problem to be solved in throat surgery. Circular RNA (circRNA) is a kind of endogenous loop non-coding RNA formed by non-classical splicing. It may play an important role in the development and progression of various diseases through microRNA (miRNA) sponge, alternative splicing regulators and so on. It is a potential biomarker for early diagnosis of diseases or a new target for intervention therapy. With the deepening of research, the relationship between circRNA and nerve, muscle functions and related diseases has also been widely concerned by scholars. This review focuses on circRNA''s molecular characteristics, formation mechanism, mode of action, and its research progress in nerve, muscle functions and related diseases, so as to provide new ways for the treatment of advanced vocal fold paralysis. |
| |
| Keywords: | Circular RNA nervous system diseases Nerve damage muscle- related diseases |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
| 点击此处可从《第二军医大学学报》下载免费的PDF全文 |
|
