清热活血类中药注射剂治疗急性缺血性脑卒中的网状Meta分析

目的 系统评价清热活血类中药注射剂治疗急性缺血性脑卒中的有效性和安全性.方法 计算机检索中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库、PubMed、Cochrane Library,检索起止时间为建库至2020年10月.由2位研究员独立筛选文献、提取资料并按照Jadad量表对文献进行质量评价,采用S...

Network Meta-analysis of Chinese materia medica injection for resolving heat and promoting blood circulation in treatment of acute ischemic stroke

Objective To evaluate the efficacy and safety of chinese medicine injection for resolving heat and promoting blood circulation in treatment of acute ischemic stroke(AIS). Methods CNKI, VIP database(VIP), Wanfang database, PubMed and Cochrane Library were all searched until October, 2020. Two researchers independently screened the literature, extracted the data, and evaluated the quality of the literature according to the Jadad scale. Stata 16.0 was used for statistical analysis. Results A total of 66 studies were included, with a total sample size of 7142 cases. The measures included three Chinese medicine injections, including Xingnaojing Injection(醒脑静注射液, XNJ), Mailuoning Injection(脉络宁注射液, MLN), and Kudiezi Injection(苦碟子注射液, KDZ). On the part of total effective rate, results of network Meta analysis showed that the rank of cumulative probability was: XNJ + CT(72.8%) > KDZ + CT(65.6%) > MLN + CT(61.6%) > CT(0.0%). In terms of NIHSS, the rank of cumulative probability was: MLN + CT(87.8%) > XNJ + CT(71.9%) > KDZ + CT(38.6%) > CT(1.7%). In the aspect of Barthel index, the rank of cumulative probability was: KDZ + CT(93.3%) > XNJ + CT(56.6%) > CT(0.0%). In the aspect of serum levels of IL-6, the rank of cumulative probability was: XNJ + CT(99.6%) > KDZ + CT(38.3%) > CT(12.1%). Conclusion For patients with AIS, XNJ shows better effect in total effective rate and serum levels of IL-6, while MLNI and KSZI show advantages in improving NIHSS score and Barthel index, respectively. However, limited by the quality of the included studies, this conclusion still needs to be further verified by high-quality studies.