血清前白蛋白在围手术期脊柱结核患者的变化研究

目的:观察围手术期脊柱结核患者的血清前白蛋白(PA)水平,初步探讨其对临床诊治的指导价值.方法:选取2013年6月—2017年6月我院收治的162名脊柱结核患者作为研究对象,以年龄大于65岁为老年组、小于65岁为非老年组,其中老年组35例,非老年组127例.男82例,女80例.化疗方案为3 HREZ/5-7 HRE,手...

Changes in Serum Prealbumin following Spinal Tuberculosis Surgery

Objective To explore the trend of changes in the serum prealbumin(PA)level in patients with spinal tuberculosis during perioperative period.Methods A retrospective study was performed by enrolling 162 patients with spinal tuberculosis who had been admitted to ourhospital from June 2013 to June 2017,including 82 males and 80 females.Included patients were then assigned to the elderly group(age≥65 years,n=35)and the non-elderly group(age<65 years,n=127).The chemotherapy regimen was 3HREZ/5-7HRE,which in combination with preoperative anti-tuberculosis treatment and nutritional support for 3 to 4 weeks,as well asone-stage debridement and(or)bone graft fusion and internal fixation.The serum PA levels of patients with spinal tuberculosis at admission,prior to surgery and at 2 and 4 weeks after surgery were collected.Results There was a gradual increased trend in the PA level from admission to prior to surgery and at 2 and 4 weeks after surgeryin all patients(0.14±0.03)g/L<(0.16±0.04)g/L<(0.22±0.04)g/L<(0.25±0.04)g/L].The increase in the non-elderly group was much higher than that in the elderly group,which the difference was statistically significant(P<0.01).Conclusion Changes in serum PA level in patients with spinal tuberculosis during perioperative period are consistent with the trend of control of inflammation and nutrition improvement of nutrition.The relationship between the changes and the timing of surgery deserves to be observed in the future research.