加味黄连解毒汤联合西药治疗幽门螺杆菌感染性胃溃疡临床研究

目的:观察加味黄连解毒汤联合西药治疗幽门螺杆菌感染性胃溃疡的临床疗效及对血清炎症因子的影响。方法:将幽门螺杆菌感染性胃溃疡患者114例,按照随机数字表法分为2组,各57例。对照组应用甲硝唑、阿莫西林胶囊、西咪替丁片治疗,观察组在对照组的基础上加用加味黄连解毒汤治疗。2组均治疗4周,观察比较2组临床疗效及不良反应,2组治疗前后血清白细胞介素-6 (IL-6)、白细胞介素-17 (IL-17)及干扰素-γ(IFN-γ)水平变化。结果:观察组总有效率为91.22%,对照组为75.43%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清IL-6、IL-17水平均较治疗前降低(P<0.05),IFN-γ水平较治疗前升高(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。观察组不良反应发生率为5.26%,对照组为5.26%,2组比较,差异无统计学意义(P>0.05)。结论:加味黄连解毒汤联合西药治疗幽门螺杆菌感染性胃溃疡疗效显著,可有效减轻患者炎症反应,效果优于单纯西药治疗。

Clinical Study on Modified Huanglian Jiedu Tang Combined with Western Medicine for Gastric Ulcer Infected by Helicobacter Pylori

Objective:To observe the clinical effect of modified Huanglian Jiedu tang combined with western medicine for gastric ulcer infected by helicobacter pylori and its effect on serum inflammatory factors. Methods:A total of 114 cases of patients with gastric ulcer infected by helicobacter were divided into two groups according to the random number table method, 57 cases in each group. The control group was treated with metronidazole, amoxicillin capsules and cimetidine tablets,and the observation group was additionally treated with modified Huanglian Jiedu tang based on the treatment of the control group. Both groups were treated for four weeks. The changes in the levels of interleukin-6(IL-6),interleukin-17(IL-17)and interferon-γ(IFN-γ) in serum before and after treatment,the clinical effect and adverse reactions in the two groups were observed and compared. Results:The total effective rate was 91.22% in the observation group and 75.43% in the control group,the difference being significant(P<0.05). After treatment,the levels of IL-6 and IL-17 in serum in the two groups were decreased when compared with those before treatment(P<0.05), and IFN-γ levels were increased(P<0.05);the improvement of all the above indexes in the observation group was more significant than that in the control group(P<0.05).Conclusion: The therapy of modified Huanglian Jiedu tang combined with western medicine for gastric ulcer infected by helicobacter has significant clinical effect and can effectively relieve the inflammatory responses of patients,whose effect is better than that of simple western medicine.