富血小板血浆联合加巴喷丁治疗带状疱疹性神经痛的效果观察

目的 观察富血小板血浆联合加巴喷丁治疗带状疱疹性神经痛的临床疗效.方法 选择2019-10～2020-04于广西医科大学第二附属医院疼痛科就诊的带状疱疹性神经痛患者36例,采用随机数字表法将其分为观察组和对照组,每组18例.对照组予常规抗病毒及口服加巴喷丁治疗,观察组在此基础上加用超声引导下富血小板血浆注射靶神经治疗....

Effect of platelet-rich plasma combined with gabapentin on zoster-related neuralgia

Objective To observe the clinical efficacy of platelet-rich plasma combined with gabapentin in treatment of zoster-related neuralgia.Methods Thirty-six patients with zoster-related neuralgia treated in the Department of Pain Management of the Second Affiliated Hospital of Guangxi Medical University from October 2019 to April 2020 were selected,and were divided into observation group and control group by random number table method,with 18 cases in each group.The control group was treated with routine antiviral therapy and oral gabapentin treatment.The observation group was treated with the same treatment as the control group plus ultrasound-guided injection of platelet-rich plasma into target nerve.The clinical efficacy and pain degree were compared between the two groups,and the occurrence of adverse reactions during the treatment of the two groups were recorded.Results After treatment,the Numerical Rating Scale(NRS)scores in both groups showed a downward trend,and the differences were statistically significant compared with those before treatment in the same group(P<0.05).After treatment,the NRS scores of the observation group were significantly lower than those of the control group at each time point(P<0.05).In the observation group,13 cases were clinically cured,4 cases clinically improved,and 1 case ineffective;in the control group,6 cases were clinically cured,6 cases clinically improved,and 6 cases ineffective.The clinical effect of the observation group was better than that of the control group(Z=2.491,P=0.013).There were no serious adverse reactions during the treatment of the two groups.Conclusion Compared with traditional drug therapy alone,ultrasound-guided platelet-rich plasma injection has the advantages of better analgesic effect and less adverse reactions in treatment of zoster-related neuralgia,which provides a new idea for the treatment of zoster-related neuralgia.