糖尿病与非糖尿病急性脑梗死患者非痴呆性血管性认知障碍的相关因素差异分析

目的 研究2型糖尿病(diabetes mellitus type 2,T2DM)与非T2DM的急性脑梗死患者非痴呆性血管性认知障碍(vascular cognitiveimpairment no dementia,VCIND)的相关因素差异.方法 连续选择发病2周以内的,首次诊断为急性脑梗死患者,将其中符合VCIND...

Differential analysis of factors related to vascular cognitive impairment no dementia in diabetic and non-diabetic patients with acute cerebral infarction

Objective To investigate the different factors related to vascular cognitive impairment no dementia (VCIND) in T2DM and non-T2DM patients complicated with acute cerebral infarction. Methods Patients, who was diagnosed with acute cerebral infarction for the first time (within 2 weeks of onset) and met the classification and diagnostic criteria of Guidelines for Diagnosis and Treatment of Vascular Cognitive Impairment formulated by dementia and cognitive impairment group of neurology branch of the Chinese Medical Association (2011 edition), were enrolled in the study. Clinical data on the general condition, biological factors and lab results were reviewed. The patients were divided into two groups, T2DM group and non-T2DM group. The differences of the general conditions, biological factors, total score of MoCA scale, and various parts of MoCA between the two groups were compared. Results In comparison between T2DM and non-T2DM groups, the proportion of patients with carotid atherosclerosis in T2DM group was higher (P=0.002), the total MoCA score was lower in T2DM group (P=0.047). Compared with non-T2DM group, the scores of executive test and memory test in T2DM group were lower (P=0.025 and P=0.001, respectively). There were not statistically significant differences in other scores. Conclusion Comparision of VCIND in T2DM and non-T2DM patients with acute cerebral infarction demonstrates that the proportion of patients with carotid atherosclerosis in T2DM group is higher, and the cognitive impairment is more serious.