五淋化石丸联合黄酮哌酯治疗慢性非细菌性前列腺炎的临床研究

目的探讨五淋化石丸联合黄酮哌酯治疗慢性非细菌性前列腺炎的临床疗效。方法选取2018年1月—2020年1月在驻马店市中心医院泌尿一科住院治疗的134例慢性非细菌性前列腺炎患者,随机分成对照组(n=67)和治疗组(n=67)。对照组口服盐酸黄酮哌脂片,0.2g/次,3次/d。治疗组在对照组的基础上口服五淋化石丸,5丸/次,3次/d。两组均同时治疗7d。观察两组的临床疗效,比较两组治疗前后NIH-CPSI评分和血清炎性因子的变化情况。结果治疗后,治疗组总有效率97.01%显著高于对照组的74.63%(P<0.05)。治疗后,两组疼痛症状评分、排尿症状评分、生活质量评分均显著降低(P<0.05);治疗后,治疗组NIH-CPSI评分显著低于对照组(P<0.05)。治疗后,两组患者白细胞介素4(IL-4)、白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)水平均显著降低(P<0.05);治疗后,治疗组血清炎性因子水平低于对照组(P<0.05)。结论五淋化石丸联合黄酮哌酯治疗慢性非细菌性前列腺炎临床疗效显著,能有效改善尿频、尿急、尿痛等症状,降低炎症因子的水平,值得临床借鉴与参考。

Clinical study of Wulin Huashi Pills combined with flavonolate in treatment of chronic abacterial prostatitis

Objective To explore the feasibility inhaled atomized Xiyanping Injection through determination of aerodynamic characteristics of atomized fine particles and safety of atomized inhalation in mice provide reference for clinical application. Mehtods The new generation of cascade impactor and atomizer system (There were two kinds of atomizers, the compressed air atomizer:Germany Bray medical atomizer Turbo BOY N and the ultrasonic atomizer:Yuyue medical atomizer 503M) was used with COPLEY Scientific Limited CITDAS software to calculate mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD) and fine particle fraction (FPF). The total delivery amount and delivery rate of Xiyanping Injection were measured by respiratory simulator. Inexpose inhalation exposure system was used, mice were exposed to low, medium and high doses of Xiyanping injection (25, 50 and 125 mg/kg, which were 3, 6 and 15 times of the clinical equivalent dose) through oral and nasal inhalation for 4 consecutive weeks, withdrawal for two weeks of drug, mice in the control group inhaled normal air. To observe the general state of mice, 10 mice in each group were killed at the end of the administration period and the end of the recovery period, half male and half female. Blood samples were taken before the mice were killed to detect the changes of hematological indexes and serum biochemistry; autopsy was performed after the animals were anesthetized with ether inhalation, and the appearance of the tissues was observed in situ, focusing on the oral mucosa, nasal septum mucosa, trachea and lung; the main organs brain, liver, spleen, kidney, heart and lung were dissected to detect the organ coefficient; the left lung was stained with HE to observe the histopathology change. Results Xiyanping Injection can be atomized into the lungs (bronchi and bronchioles) and a certain proportion of it remains in the lungs. The total delivery amount and delivery rate of Xiyanping Injection increase in turn in children and adults. The results of inhalation irritation showed that no death and cough were observed during the experiment. Compared with control group, there were no significant changes in hematological indexes, serum biochemistry, organ coefficient, main histological examination and lung histopathology in all dose groups of Xiyanping Injection. Conclusion Under the condition of in vitro the existing nebulized inhalation, Xiyanping Injection can be inhaled into the lungs (bronchi, bronchioles) and a high proportion of drugs remain in the lungs, and there was no obvious irritation to the respiratory mucosa, indicating that the application of nebulized inhalation is relatively safe and feasible.