基于数据挖掘探析卵泡发育不良性不孕的中医临床用药规律

[目的]分析卵泡发育不良性不孕的中医用药规律,总结疾病特点和临床治疗思路,以期为中医药治疗本病提供借鉴.[方法]检索自建库起至2019年12月中国知网(China National Knowledge Infrastructure,CNKI)、万方数据库(WanFang Database)、维普中文科技期刊数据库(Ch...

Exploring the Medication Rules of Follicular Maldevelopment Infertility Based on Data Mining

[Objective] To analyse the medication rules of traditional Chinese medicine(TCM) for follicular maldevelopment(FM) infertility and summarize the disease characteristics and clinical treatment ideas, in order to provide instructions for the treatment of FM infertility with TCM. [Methods] The literature of clinical research and personal experience about treating FM infertility with TCM, published from the establishment of the database to December 2019, included in China National Knowledge Infrastructure(CNKI),WanFang Database and China Science and Technology Journal Database(VIP Database) were retrieved. The information of medical records was collected and extracted, and based on "Ancient and Modern Medical Records Cloud Computing Platform V1.4", the medication database was established for frequency analysis. The factor analysis and cluster analysis were conducted by SPSS 23.0 statistical software, and the association rules were analyzed by using Apriori algorithm. [Results] There were 62 formulas, 64 drugs, 20 drug efficacy and 362 frequencies in 52 medical literatures. Frequency analysis showed that the top six types of frequently applied drugs were Cuscuta chinensis, Cornus officinalis, Angelicae sinensis, Cynanchum otophyllum, Rehmannia glutinosa, Radix Rehmanniae Preparata. The top three properties were mild, slightly cold and warm. The top three tastes were sweetness, acridity and bitterness, with sweetness as the dominance. The main meridian entries were liver, kidney, spleen and heart. The association rules analysis showed that subdrugs from the Yangjing Zhongyu Decoction were closely linked, and the subdrugs had close connection with warming Yang drugs. Two central drugs groups were obtained through clustering analysis, and both groups had the effect of tonifying Yin and Yang of the liver and kidney, nourishing blood and regulating menstruation. The first group of drugs focused on nourishing Yin and supplementing Yang to tonify the kidney Yang, and nourishing blood;the second group of drugs focused on nourishing the kidney Yin and tonifying the kidney essence. [Conclusion] Clinically, TCM treatment of FM infertility medication takes replenishing the liver and kidney as the main treatment principle, nourishing Yin as the main, warming Yang as the auxiliary, mildly regulating Yin and Yang.