| 阿司匹林衍生物药理活性研究概述 |
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| 作者姓名： | 吴定浩 邢志华 李兴杨 王琪琪 包然 程美池 张凤阳 |
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| 作者单位： | 哈尔滨商业大学，中央与地方共建高等学校药学重点实验室，黑龙江省预防与治疗老年病药物研究重点实验室，国家教育部抗肿瘤天然药物研究工程中心，黑龙江 哈尔滨 150076 |
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| 基金项目： | 黑龙江省自然科学基金面上项目（No.H2016001）；大学生创新训练计划项目（No.201910240091）；哈尔滨商业大学校级科研项目（No18XN082） |
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| 摘 要： | 阿司匹林具有多种药理活性,是老药新用的典型药物之一。近年来,人们为开发阿司匹林,对其结构进行修饰及改造,以期得到副作用更小、活性更好的衍生物。本文总结了30种阿司匹林衍生物的合成路线及药理活性。其药理活性主要集中在解热镇痛、抗炎、抗骨质疏松、防治心脑血管疾病及抗肿瘤活性等方面,可为相关研究和应用提供参考。
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| 关 键 词： | 阿司匹林衍生物 结构修饰 药理活性 |
Overview of pharmacological activities of aspirin derivatives |
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| Authors: | WU Dinghao XING Zhihu LI Xingyang WANG Qiqi BAO Ran CHENG Meichi ZHANG Fengyang |
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| Institution: | School of Pharmacy, Harbin University of Commerce,Key Laboratory of Pharmacy Constructed by Central and Local,Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang Province,Engineering Research Center of Natural Antineoplastic Drugs,Ministry of Education,Harbin 150076,China |
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| Abstract: | Aspirin, with a variety of pharmacological activities,is one of the typical conventional drugs with new use. In recent years, its derivatives were obtained via modifying and transforming its structure in order to enhance its activities and deduce its side effects. In this paper, 30 aspirin derivatives were summarized in the synthetic routes and pharmacological activities. The pharmacological activities of 30 aspirin derivatives mainly focus on antipyretic analgesia, anti-inflammatory, anti-osteoporosis, prevention and treatment of cardiovascular and cerebrovascular diseases,anti-tumor activities and so on. It can provide reference for related research and application. |
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| Keywords: | Aspirin derivatives Structural modification Pharmacological activities |
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