薏苡仁汤加减联合双氯芬酸钠片治疗急性痛风性关节炎临床研究

目的:观察薏苡仁汤加减联合双氯芬酸钠片治疗湿热蕴结证急性痛风性关节炎(AGA)的临床疗效。方法:将60例湿热蕴结证AGA患者按随机数字表法分为观察组与对照组,各30例。对照组采用双氯芬酸钠片等治疗,观察组在对照组的基础上加用薏苡仁汤加减内服、外用治疗。7 d为1个疗程,治疗1个疗程后比较2组临床疗效、疼痛改善程度及血尿酸(UA)、C-反应蛋白(CRP)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)水平变化。结果:观察组治疗总有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组轻度疼痛、重度疼痛占比分别为73.33%、3.33%,对照组分别为40.00%、23.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者UA、CRP、IL-6、IL-8水平均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。结论:薏苡仁汤加减联合双氯芬酸钠片治疗湿热蕴结证AGA疗效显著,可有效控制炎症发展,缓解临床症状。

Clinical Study on Modified Yiyiren Tang Combined with Diclofenac Sodium Tablets for Acute Gouty Arthritis

Objective:To observe the clinical effect of modified Yiyiren tang combined with diclofenac sodium tablets on acute gouty arthritis(AGA) with damp-heat accumulation syndrome. Methods:A total of 60 cases of AGA patients with dampheat accumulation syndrome were divided into the observation group and the control group according to the random number table method,30 cases in each group. The control group was treated with diclofenac sodium tablets,while the observation group was additionally treated with modified Yiyiren tang both internally and externally based on the treatment of the control group. Both groups were treated for seven days as one course. After one course,the two groups were compared in clinical effect,improvement of pain,and changes in the levels of uric acid(UA),C-reactive protein(CRP),interleukin-6(IL-6) and interleukin-8(IL-8) in serum. Results: The total effective rate was 96.67% in the observation group, higher than that of80.00% in the control group, the difference being significant(P<0.05). After treatment, the proportion of mild pain and severe pain in the observation group was 73.33% and 3.33% respectively, and that in the control group was 40.00% and23.33% respectively,the difference being significant(P<0.05). After treatment,the levels of UA,CRP,IL-6 and IL-8 in both groups were decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of modified Yiyiren tang combined with diclofenac sodium tablets has a significant therapeutic effect on AGA with damp-heat accumulation syndrome,which can control the development of inflammation and relieve clinical symptoms.