三七联合现代医学常规疗法治疗脑出血术后临床研究

目的:观察三七联合现代医学常规疗法治疗脑出血术后患者的临床疗效。方法:将100例脑出血术后患者随机分成观察组和对照组各50例。2组患者均服用地奥司明片、阿司匹林肠溶片,并给予间歇充气加压装置(IPC)和常规护理措施,观察组加予三七粉鼻肠管给药。2组疗程均为7 d。治疗前、治疗7 d后评定Caprini风险评估量表评分,检测纤维蛋白原(FIB)、D-二聚体(D-D)水平;记录治疗7 d后1个月内肺栓塞(PE)和深静脉血栓(DVT)的发生情况,记录皮下瘀血、下肢肿胀、下肢疼痛的发生情况。结果:治疗后,2组Caprini评分均较治疗前下降(P<0.01),观察组Caprini评分低于对照组(P<0.01)。2组PE发生率比较,差异无统计学意义(P>0.05)。观察组DVT发生率与静脉血栓栓塞症总发生率均低于对照组(P<0.05)。观察组皮下瘀血、下肢肿胀、下肢疼痛发生率均低于对照组,但组间比较,差异均无统计学意义(P>0.05)。2组FIB、D-D水平均较治疗前下降(P<0.01),观察组FIB、D-D水平均低于对照组(P<0.01)。结论:在常规医护措施的基础上对脑出血术后患者给予三七粉鼻肠管给药,可减轻血液高凝状态和纤溶亢进状态,降低静脉血栓栓塞的发生风险。

Clinical Study on Panax Notoginseng Combined with Conventional Modern Medical Therapy for Postoperative Cerebral Hemorrhage

Objective: To observe the clinical effect of panax notoginseng combined with conventional modern medical therapy on patients with postoperative cerebral hemorrhage. Methods: A total of 100 patients with postoperative cerebral hemorrhage were randomly divided into the observation group and the control group,50 cases in each group. Patients in the two groups were given diosamine tablets and aspirin enteric-coated tablets, and were given intermittent pneumatic pressurization(IPC) as well as routine nursing measures. Patients in the observation group were additionally given administration of panax notoginseng powder through nasointestinal tube. The course of treatment in both groups was seven days. Before treatment and seven days after treatment, the score of Caprini Risk Assessment Scale was evaluated, and levels of fibrinogen(FIB) and D-dimer(D-D) were detected. The occurrence of pulmonary embolism(PE) and deep vein thrombosis(DVT) within one month after seven days of treatment was recorded,and the occurrence of subcutaneous blood stasis, lower limb swelling and lower limb pain was also recorded. Results: After treatment, the Caprini scores in both groups were decreased when compared with those before treatment(P<0.01), and the Caprini score in the observation group was lower than that in the control group(P<0.01). There was no significant difference being found in the comparison of the incidence of PE(P>0.05). The incidence of DVT and the total incidence of venous thromboembolism in the observation group were lower than that in the control group(P<0.05). The incidences of subcutaneous stasis, lower limb swelling and lower limb pain in the observation group were lower than that in the control group,there being no significant difference being found in the comparison between the two groups(P>0.05). The FIB and D-D levels in both groups were decreased when compared with those before treatment(P<0.01),FIB and D-D levels in the observation group were lower than those in the control group(P<0.01). Conclusion: Based on conventional medical measures, the administration of panax notoginseng powder through noseintestinal tube for patients with postoperative cerebral hemorrhage can reduce hypercoagulability and fibrinolysis,and decrease the risk of venous thromboembolism.