术前参麦注射液干预对患者围术期神经认知功能紊乱影响的Meta分析

目的评价参麦注射液术前干预对患者围术期神经认知功能紊乱的影响。方法通过计算机检索中国知网、中国生物医学文献数据库、维普、万方医学、PubMed、Embase等数据库,纳入参麦注射液术前干预对改善患者围术期神经认知功能紊乱影响的随机对照试验(RCT),检索年限为建库至2020年2月。采用RevMan 5.3软件进行统计学分析。结果纳入7项RCT研究,567例患者,其中参麦干预组284例,对照组283例。参麦干预组围术期神经认知功能紊乱(PND)的发生率明显低于对照组(OR=0.26,95%CI 0.16~0.42,P<0.001),术后简易智能精神状态量表评分(MMSE)明显高于对照组(MD=3.13,95%CI 2.89~3.36,P<0.001)。结论术前应用参麦注射液进行干预能够降低患者PND的发生率。

Effects of preoperative shenmai injection intervention on perioperative neurocognitive disorders:a meta-analysis

Objective To evaluate the effectiveness of Shenmai Injection preoperative intervention in improving Perioperative Neurocognitive Disorders.
Methods By retrieving China Knowledge Network (CNKI), China Biomedical Literature Database (CBM), Weipu database, Wanfang medical database, PubMed, Embase and other databases, and randomized controlled trial (RCT) of the effect of, preoperative intervention of Shenmai Injection on the improvement of perioperative neurocognitive disorders (PND) in patients was included. The search period is limited from the establishment of the databases to February 2020. All data were extracted for statistical analysis using RevMan 5.3 software.
Results A total of 7 RCT studies were included, including 284 in Shenmai intervention group and 283 in control group. According to the current clinical trial evidence, the incidence of PND in the intervention group was lower than that in the control group (OR = 0.26, 95% CI 0.16-0.42, P < 0.001), and the mini-mental state examination (MMSE) score of the postoperative appeared significantly superior to that in the control group (MD = 3.13, 95% CI 2.89-3.36, P < 0.001).
Conclusion According to existing clinical trials, it has been shown that intervention with Shenmai Injection before surgery is possible to reduce the incidence of PND.