内镜下抗反流黏膜切除术治疗难治性胃食管反流病初探

目的 探讨内镜下抗反流黏膜切除术(ARMS)治疗难治性胃食管反流病(RGERD)的初步疗效及安全性。方法 回顾性分析2017年6月-2019年1月宁波市第一医院6例行ARMS治疗的RGERD患者的临床资料,治疗前后行反流症状指数(RSI)、胃食管反流病健康相关生存质量量表(GERD-HRQL)及吞咽困难评分,评价治疗的疗效。结果 全组6例患者均顺利完成内镜下ARMS术,无术中术后穿孔、出血等严重并发症。术后随访至少6个月,最长至26个月。术后1个月RSI评分及GERD-HRQL评分为(9.7±3.9)和(11.3±2.3)分,与术前比较,差异均有统计学意义(P0.01);术后6个月RSI评分及GERD-HRQL评分为(2.8±1.5)和(3.2±1.9)分,与术前比较,差异均有统计学意义(P0.01)。术后1个月吞咽困难症状改善尚不明显(P0.05),术后6个月无1例患者存在吞咽困难评分为(0.0±0.0)分],与术前比较,差异有统计学意义(P0.05)。结论 内镜下ARMS术治疗RGERD的短期疗效好,安全性高。

Preliminary results of anti-reflux mucosectomy in treatment of refractory gastroesophageal reflux disease

Abstract: Objective?To evaluate the safety and efficacy of endoscopic anti-reflux mucosectomy (ARMS) for refractory gastroesophageal reflux disease.?Methods?6 patients who underwent anti-reflux mucosectomy from June 2017 to January 2019 were enrolled in this study, and the clinical data were analyzed retrospectively. RSI, GERD-HRQL and dysphagia scores were used before and after the operation for evaluation of curative effect of anti-reflux mucosectomy.?Results?6 patients underwent anti-reflux mucosectomy successfully. No major adverse events such as perforation or bleeding was found in perioperative period. The patients were followed up for at least 6 months, and the longest follow-up time was up to 26 months. RSI and GERD-HRQL scores were (9.7?±?3.9) and (11.3?±?2.3) respectively one month after ARMS (P??0.05), but no patients felt dysphagia 6 months after ARMS The score is (0.0±0.0), P?