脑利钠肽联合红细胞分布宽度在婴儿川崎病中的应用价值

目的:深入探讨脑利钠肽和红细胞分布宽度在婴儿川崎病冠状动脉病变中的应用价值,预防和减少冠状动脉病变,从而改善川崎病患儿的预后。方法:回顾性分析2018年1月—2019年12月在郑州大学附属儿童医院收治的已经出院确诊为婴儿川崎病的113例患儿的临床资料,并对其进行总结分析。结果:CAL组WBC、RDW和BNP水平显著升高,差异有统计学意义。WBC、RDW和BNP水平增高是CAL的独立危险因素。RDW≥13.4%预测川崎病合并冠脉病变的灵敏度为74.4%,特异度为75.7%,ROC曲线下的面积为0.757。BNP≥325 pg/m L预测川崎病合并冠脉病变的灵敏度为90.7%,特异度为74.3%,ROC曲线下的面积为0.862。结论:BNP、RDW升高可作为预测川崎病患儿合并CAL的危险因素。

Application Value of Brain Natriuretic Peptide and Red Blood Cell Distribution Width in Infant Kawasaki Disease

OBJECTIVE To explore the application value of brain natriuretic peptide and red blood cell distribution width in infant Kawasaki disease coronary artery disease,to prevent and reduce coronary artery disease,so as to improve the prognosis of children with Kawasaki disease.METHODS Retrospectively analyze the clinical data of 113 infants with Kawasaki disease diagnosed as Kawasaki disease in target hospital from January 2018 to December 2019.RESULTS The levels of WBC,RDW and BNP in the CAL group increased significantly,the difference was statistically significant.Increased levels of WBC,RDW and BNP were independent risk factors for CAL.The sensitivity and specificity of RDW≥13.4%were 74.4%and 75.7%in predicting infant KD with CAL respectively,the area under the ROC curve(AUC)was 0.757.The sensitivity and specificity of BNP≥325 pg/ml were 90.7%,and 74.3%in predicting infant KD with CAL respectively,the area under the ROC curve(AUC)was 0.862.CONCLUSION Increased levels of BNP and RDW could be used as risk factors for predicting CAL in infants with KD.