闭塞性细支气管炎的治疗进展

闭塞性细支气管炎（BO）是一种少见的不可逆性慢性小气道阻塞性肺疾病,表现为反复持续性咳嗽、喘息,运动不耐受,难以消退的肺部喘鸣音及细湿性啰音。BO是一种组织病理学概念,临床上主要包括移植后出现的闭塞细支气管炎综合征（BOS）和感染后闭塞性细支气管炎（PIBO）。目前BO无确定的治疗方案,治疗以糖皮质激素、大环内酯类抗生素、白三烯受体拮抗剂等抗炎治疗、免疫抑制剂、靶向治疗和对症支持治疗为主。本文对近5年来闭塞性细支气管炎的治疗进展进行综述。

Treatment Progress in Bronchiolitis Obliterans

Bronchiolitis obliterans (BO) is a rare, irreversible, chronic form of obstructive lung disease in small airways characterized by repeated persistent cough, wheezing and exercise intolerance. Lung stridor and fine moist rale are hard to fade. BO is a histopathological concept, which mainly includes bronchiolitis obliterans syndrome (BOS) and post-infectious bronchiolitis obliterans (PIBO). The treatment options have not been clearly defined, which is usually based on anti-inflammatory therapy such as corticosteroids, macrolides, leukotriene receptor antagonists, combination with immunosuppressants, targeted therapy and support therapy. Here we present the progress in the treatment of bronchiolitis obliterans in recent 5 years.