99Tcm-奥曲肽眼眶显像联合MRI在TAO分期诊断中的效能

目的:探讨99Tcm-奥曲肽眼眶显像联合核磁共振成像(MRI)在甲状腺相关性眼病(TAO)分期诊断中的效能。方法:回顾性分析2017-06/2018-06收治的35例接受手术治疗的TAO患者的临床资料,均行99Tcm-奥曲肽眼眶显像联合MRI检查,手术取材进行病理学观察,并进行病理分期。统计病理分期结果,观察99Tcm-奥曲肽眼眶显像联合MRI检查的影像学表现和结果,分析99Tcm-奥曲肽眼眶显像、MRI、99Tcm-奥曲肽眼眶显像联合MRI检查对TAO分期诊断的效能。结果:35例TAO患者共58眼患病,经病理分期为活动期(49眼)、非活动期(9眼);99Tcm-奥曲肽眼眶显像和MRI诊断TAO分期均有典型影像学表现,且99Tcm-奥曲肽眼眶显像联合MRI诊断活动期TAO的灵敏度、特异度、准确度均高于单独应用99Tcm-奥曲肽眼眶显像、MRI检查,且ROC结果显示99Tcm-奥曲肽眼眶显像联合MRI诊断活动期的AUC为0.893,高于99Tcm-奥曲肽眼眶显像或MRI单独诊断。结论:对TAO分期诊断中建议联合应用99Tcm-奥曲肽眼眶显像和MRI影像学检查,二者影像学表现典型,且联合应用具有较高诊断效能。

Efficacy of 99Tcm-Octreotide orbital imaging combined with MRI in stage diagnosis of TAO

AIM:To investigate the efficacy of 99Tcm-octreotide orbital imaging combined with magnetic resonance imaging(MRI)in stage diagnosis of thyroid associated ophthalmopathy(TAO).

METHODS: Retrospective analysis of clinical data of 35 surgically treated TAO patients admitted to hospital from June 2017 to June 2018. 99Tcm-octreotide orbital imaging and MRI were performed, and the pathological observation and stages were performed. The result of pathological staging was statistically analyzed. The imaging findings and results of 99Tcm-octreotide orbital imaging combined with MRI were observed. The efficacy of 99Tcm-octreotide orbital imaging, MRI, 99Tcm-octreotide orbital imaging combined with MRI in the stage diagnosis of TAO was analyzed.

RESULTS: Totally 58 eyes with TAO in 35 patients with pathological stages were 49 eyes in the active phases and 9 eyes and inactive phases. 99Tcm-octreotide orbital imaging and MRI diagnosis of TAO severity staging have typical imaging findings, and the sensitivity, specificity, accuracy of 99Tcm-octreotide orbital imaging combined with MRI in the diagnosis of active TAO was higher than that of 99Tcm-octreotide orbital imaging and MRI alone. The ROC results showed that the AUC of the active phase of 99Tcm-octreotide orbital imaging combined with MRI diagnosis was 0.893, which was higher than that of 99Tcm-octreotide orbital imaging or MRI alone.

CONCLUSION:It is recommended to use 99Tcm-octreotide orbital imaging and MRI imaging in combination with TAO stage diagnosis. The imaging findings are typical, and the combined application has higher diagnostic efficiency.