宽苞糙苏根降三萜化学成分研究

目的 研究宽苞糙苏Phlomis umbrosa var.latibracteata根降三萜类化学成分.方法 用硅胶柱色谱、凝胶柱色谱、以及制备高效液相色谱等多种色谱分离手段进行分离纯化,用有机波谱手段鉴定分离得到的化合物结构.结果 从宽苞糙苏根的95％乙醇提取物中分离得到8个降三萜类化合物,分别鉴定为糙苏醛A(1)、...

Study on nortriterpenes from roots of Phlomis umbrosa var. latibracteata

Objective To study the nortriterpenes from the root of Phlomis umbrosa var. latibracteata. Methods The chemical constituents were isolated by repeated column chromatographies (Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. Results Eight nortriterpenes were isolated from the 95% ethanol aqueous extract of P. umbrosa var. latibracteata and the structures were identified as phlomisal A (1), phlomisone (2), phlomistetraol A (3), phlomistetraol B (4), phlomishexaol A (5), phlomishexaol B (6), phlomishexaol C (7), and phlomishexaol D (8). Conclusion Compound 1 is a new compound, and compounds 3, 4, 6-8 are isolated from this plant for the first time. All the nortriterpenes display varying degrees of antitumor activities against cancer cells in vitro.