DCE-MRI及多b值DWI对卵巢上皮源性肿瘤良恶性的鉴别诊断价值

目的:探讨动态对比增强MRI(DCE-MRI)及多b值DWI对卵巢上皮源性肿瘤良恶性的鉴别诊断价值.方法:搜集经术后病理证实为卵巢上皮源性肿瘤的39例患者,术前行常规MRI平扫及增强、多b值DWI及DCE-MRI检查,与术后病理结果进行对照,分别测量卵巢肿瘤实性区域及囊性区域的ADC值及DCE-MRI定量参数.采用RO...

DCE-MRI and multi-b-value DWI for differentiating benign from malignant ovarian epithelial tumor

Objective:To investigate the value of dynamic contrast enhanced-MR imaging(DCE-MRI)and mulit-b-value diffusion weighted imaging(DWI)in differentiating malignant from benign ovarian epithelial tumor.Methods:39 patients with ovarian epithelial tumor confirmed by postoperative pathology were collected.All patients underwent mulit-b-value DWI and DCE-MRI.The apparent diffusion coefficient(ADC),and DCE-MRI quantitative parameters(Ktrans,Kep and Ve values)were measured on solid and cystic portion of ovarian tumor,respectively.Receiver operating characteristic(ROC)curve was performed to determine diagnostic performance.Results:There were statistically significant differences in ADC values between benign and malignant ovarian epithelial tumor in both the solid and the cystic portion(P<0.05).DCE-MRI quantitative parameters had statistically significant differences in the solid portion of benign and malignant ovarian epithelial tumors(P<0.05).With b value of 1200s/mm 2 and thresholds of 1149.9mm 2/s for ADC of solid portion,DWI had AUC,Se and Sp of 0.874,88.2%and 86.4%,respectively;with thresholds of 2640.2mm 2/s for ADC of cystic portion,DWI had AUC,Se and Sp of 0.893,73.7%and 88.2%,respectively.For DCE-MRI,Ktrans values achieved the highest diagnostic efficiency among three quantitative parameters.With thresholds of 0.0925min-1 for Ktrans,DWI had AUC,Se and Sp of,0.840,77.3%and 82.4%,respectively.The combination of DCE-MRI and mulit-b-value DWI showed the best diagnostic performance for discrimination malignant from benign ovarian epithelial tumor with Se,Sp,PPV,NPV and ACC of 95.7%,100%,94.1%,100%and 97.4%,respectively.Conclusion:ADC(b=1200s/mm 2)and Ktrans values may be valuable for differentiation of malignant from benign ovarian epithelial tumors.The combination of DCE-MRI with mulit-b-value DWI can further improve the diagnostic performance.